Concise review: Fat and furious: Harnessing the full potential of adipose-derived stromal vascular fraction

Jordan A. Dykstra, Tiffany Facile, Ryan J. Patrick, Kevin R. Francis, Samuel Milanovich, Jill M. Weimer, Daniel J. Kota

Research output: Contribution to journalReview article

23 Scopus citations

Abstract

Due to their capacity to self-renew, proliferate and generate multi-lineage cells, adult-derived stem cells offer great potential for use in regenerative therapies to stop and/or reverse degenerative diseases such as diabetes, heart failure, Alzheimer’s disease and others. However, these subsets of cells can be isolated from different niches, each with differing potential for therapeutic applications. The stromal vascular fraction (SVF), a stem cell enriched and adipose-derived cell population, has garnered interest as a therapeutic in regenerative medicine due to its ability to secrete paracrine factors that accelerate endogenous repair, ease of accessibility and lack of identified major adverse effects. Thus, one can easily understand the rush to employ adipose-derived SVF to treat human disease. Perhaps faster than any other cell preparation, SVF is making its way to clinics worldwide, while critical preclinical research needed to establish SVF safety, efficacy and optimal, standardized clinical procedures are underway. Here, we will provide an overview of the current knowledge driving this phenomenon, its regulatory issues and existing studies, and propose potential unmapped applications.

Original languageEnglish (US)
Pages (from-to)1096-1108
Number of pages13
JournalStem Cells Translational Medicine
Volume6
Issue number4
DOIs
Publication statusPublished - Apr 2017

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Keywords

  • Adipose
  • Adult stem cells
  • Autologous stem cell transplantation
  • Cellular therapy
  • Clinical trials
  • Mesenchymal stem cells

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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