Computational modelling and simulation of disposition and fate of medication

Dietmar P F Möller, Hamid Vakilzadian, Jochen Wittmann

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this case study, the ingestion and subsequent metabolism of a medication in an individual are examined through computational modeling and simulation. A multi-compartment model is used to study ingestion, distribution, and metabolism of a medication in an individual. This paper provides background information on the mechanism of action of medication in pharmacological terms and the significance of pharmacokinetic parameters in determining the efficacy of a medication, in particular, the medication that is ingested orally. The orally taken medication enters the gastrointestinal tract from where it is then distributed throughout the bloodstream of the individual to be metabolized and eliminated.

Original languageEnglish (US)
Title of host publicationProceedings of the 2011 - Grand Challenges in Modeling and Simulation Conference, GCMS 2011
Pages76-82
Number of pages7
StatePublished - Dec 1 2011
Event4th Grand Challenges in Modeling and Simulation Conference, GCMS 2011 - The Hague, Netherlands
Duration: Jun 27 2011Jun 30 2011

Publication series

NameProceedings of the 2011 - Grand Challenges in Modeling and Simulation Conference, GCMS 2011

Conference

Conference4th Grand Challenges in Modeling and Simulation Conference, GCMS 2011
CountryNetherlands
CityThe Hague
Period6/27/116/30/11

Fingerprint

Computational Simulation
Computational Modeling
Metabolism
Modeling and Simulation
Compartment Model
Pharmacokinetics
Efficacy
Term
Background

Keywords

  • Drug ingestion
  • Drug metabolism
  • Medicine
  • Modeling and simulation (M&S)
  • Pharmacokinetic

ASJC Scopus subject areas

  • Modeling and Simulation

Cite this

Möller, D. P. F., Vakilzadian, H., & Wittmann, J. (2011). Computational modelling and simulation of disposition and fate of medication. In Proceedings of the 2011 - Grand Challenges in Modeling and Simulation Conference, GCMS 2011 (pp. 76-82). (Proceedings of the 2011 - Grand Challenges in Modeling and Simulation Conference, GCMS 2011).

Computational modelling and simulation of disposition and fate of medication. / Möller, Dietmar P F; Vakilzadian, Hamid; Wittmann, Jochen.

Proceedings of the 2011 - Grand Challenges in Modeling and Simulation Conference, GCMS 2011. 2011. p. 76-82 (Proceedings of the 2011 - Grand Challenges in Modeling and Simulation Conference, GCMS 2011).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Möller, DPF, Vakilzadian, H & Wittmann, J 2011, Computational modelling and simulation of disposition and fate of medication. in Proceedings of the 2011 - Grand Challenges in Modeling and Simulation Conference, GCMS 2011. Proceedings of the 2011 - Grand Challenges in Modeling and Simulation Conference, GCMS 2011, pp. 76-82, 4th Grand Challenges in Modeling and Simulation Conference, GCMS 2011, The Hague, Netherlands, 6/27/11.
Möller DPF, Vakilzadian H, Wittmann J. Computational modelling and simulation of disposition and fate of medication. In Proceedings of the 2011 - Grand Challenges in Modeling and Simulation Conference, GCMS 2011. 2011. p. 76-82. (Proceedings of the 2011 - Grand Challenges in Modeling and Simulation Conference, GCMS 2011).
Möller, Dietmar P F ; Vakilzadian, Hamid ; Wittmann, Jochen. / Computational modelling and simulation of disposition and fate of medication. Proceedings of the 2011 - Grand Challenges in Modeling and Simulation Conference, GCMS 2011. 2011. pp. 76-82 (Proceedings of the 2011 - Grand Challenges in Modeling and Simulation Conference, GCMS 2011).
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