Comprehensive bioimaging with fluorinated nanoparticles using breathable liquids

Michael E. Kurczy, Zheng Jiang Zhu, Julijana Ivanisevic, Adam M. Schuyler, Kush Lalwani, Antonio F. Santidrian, John M. David, Anand Giddabasappa, Amanda J. Roberts, Hernando J. Olivos, Peter J. O'Brien, Lauren Franco, Matthew W. Fields, Liliana P. Paris, Martin Friedlander, Caroline H. Johnson, Adrian A. Epstein, Howard Eliot Gendelman, Malcolm R. Wood, Brunhilde H. FeldingGary J. Patti, Mary E. Spilker, Gary Siuzdak

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Fluorocarbons are lipophobic and non-polar molecules that exhibit remarkable biocompatibility, with applications in liquid ventilation and synthetic blood. The unique properties of these compounds have also enabled mass spectrometry imaging of tissues where the fluorocarbons act as a Teflon-like coating for nanostructured surfaces to assist in desorption/ionization. Here we report fluorinated gold nanoparticles (f-AuNPs) designed to facilitate nanostructure imaging mass spectrometry. Irradiation of f-AuNPs results in the release of the fluorocarbon ligands providing a driving force for analyte desorption. The f-AuNPs allow for the mass spectrometry analysis of both lipophilic and polar (central carbon) metabolites. An important property of AuNPs is that they also act as contrast agents for X-ray microtomography and electron microscopy, a feature we have exploited by infusing f-AuNPs into tissue via fluorocarbon liquids to facilitate multimodal (molecular and anatomical) imaging.

Original languageEnglish (US)
Article number5998
JournalNature communications
Volume6
DOIs
StatePublished - Jan 20 2015

Fingerprint

Fluorocarbons
fluorocarbons
Nanoparticles
Mass spectrometry
Mass Spectrometry
nanoparticles
mass spectroscopy
Liquids
liquids
Imaging techniques
Desorption
Liquid Ventilation
desorption
Blood substitutes
Tissue
X-Ray Microtomography
Molecular Imaging
Nanostructures
metabolites
ventilation

ASJC Scopus subject areas

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Kurczy, M. E., Zhu, Z. J., Ivanisevic, J., Schuyler, A. M., Lalwani, K., Santidrian, A. F., ... Siuzdak, G. (2015). Comprehensive bioimaging with fluorinated nanoparticles using breathable liquids. Nature communications, 6, [5998]. https://doi.org/10.1038/ncomms6998

Comprehensive bioimaging with fluorinated nanoparticles using breathable liquids. / Kurczy, Michael E.; Zhu, Zheng Jiang; Ivanisevic, Julijana; Schuyler, Adam M.; Lalwani, Kush; Santidrian, Antonio F.; David, John M.; Giddabasappa, Anand; Roberts, Amanda J.; Olivos, Hernando J.; O'Brien, Peter J.; Franco, Lauren; Fields, Matthew W.; Paris, Liliana P.; Friedlander, Martin; Johnson, Caroline H.; Epstein, Adrian A.; Gendelman, Howard Eliot; Wood, Malcolm R.; Felding, Brunhilde H.; Patti, Gary J.; Spilker, Mary E.; Siuzdak, Gary.

In: Nature communications, Vol. 6, 5998, 20.01.2015.

Research output: Contribution to journalArticle

Kurczy, ME, Zhu, ZJ, Ivanisevic, J, Schuyler, AM, Lalwani, K, Santidrian, AF, David, JM, Giddabasappa, A, Roberts, AJ, Olivos, HJ, O'Brien, PJ, Franco, L, Fields, MW, Paris, LP, Friedlander, M, Johnson, CH, Epstein, AA, Gendelman, HE, Wood, MR, Felding, BH, Patti, GJ, Spilker, ME & Siuzdak, G 2015, 'Comprehensive bioimaging with fluorinated nanoparticles using breathable liquids', Nature communications, vol. 6, 5998. https://doi.org/10.1038/ncomms6998
Kurczy ME, Zhu ZJ, Ivanisevic J, Schuyler AM, Lalwani K, Santidrian AF et al. Comprehensive bioimaging with fluorinated nanoparticles using breathable liquids. Nature communications. 2015 Jan 20;6. 5998. https://doi.org/10.1038/ncomms6998
Kurczy, Michael E. ; Zhu, Zheng Jiang ; Ivanisevic, Julijana ; Schuyler, Adam M. ; Lalwani, Kush ; Santidrian, Antonio F. ; David, John M. ; Giddabasappa, Anand ; Roberts, Amanda J. ; Olivos, Hernando J. ; O'Brien, Peter J. ; Franco, Lauren ; Fields, Matthew W. ; Paris, Liliana P. ; Friedlander, Martin ; Johnson, Caroline H. ; Epstein, Adrian A. ; Gendelman, Howard Eliot ; Wood, Malcolm R. ; Felding, Brunhilde H. ; Patti, Gary J. ; Spilker, Mary E. ; Siuzdak, Gary. / Comprehensive bioimaging with fluorinated nanoparticles using breathable liquids. In: Nature communications. 2015 ; Vol. 6.
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