Composite living fibers for creating tissue constructs using textile techniques

Mohsen Akbari, Ali Tamayol, Veronique Laforte, Nasim Annabi, Alireza Hassani Najafabadi, Ali Khademhosseini, David Juncker

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

The fabrication of cell-laden structures with anisotropic mechanical properties while having a precise control over the distribution of different cell types within the constructs is important for many tissue engineering applications. Automated textile technologies for making fabrics allow simultaneous control over the color pattern and directional mechanical properties. The use of textile techniques in tissue engineering, however, demands the presence of cell-laden fibers that can withstand the mechanical stresses during the assembly process. Here, the concept of composite living fibers (CLFs) in which a core of load bearing synthetic polymer is coated by a hydrogel layer containing cells or microparticles is introduced. The core thread is drawn sequentially through reservoirs containing a cell-laden prepolymer and a crosslinking reagent. The thickness of the hydrogel layer increases linearly with to the drawing speed and the prepolymer viscosity. CLFs are fabricated and assembled using regular textile processes including weaving, knitting, braiding, winding, and embroidering, to form cell-laden structures. Cellular viability and metabolic activity are preserved during CLF fabrication and assembly, demonstrating the feasibility of using these processes for engineering functional 3D tissue constructs.

Original languageEnglish (US)
Pages (from-to)4060-4067
Number of pages8
JournalAdvanced Functional Materials
Volume24
Issue number26
DOIs
StatePublished - Jul 9 2014

Fingerprint

fiber composites
textiles
Textiles
Hydrogel
Tissue
Tissue engineering
Hydrogels
Fibers
Drawing (graphics)
Composite materials
Bearings (structural)
Optical fiber fabrication
cells
Cross-Linking Reagents
prepolymers
Mechanical properties
tissue engineering
Crosslinking
Polymers
assembly

Keywords

  • fiber-based techniques
  • living fibers
  • textile technology
  • tissue engineering
  • weaving

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Condensed Matter Physics
  • Electrochemistry

Cite this

Akbari, M., Tamayol, A., Laforte, V., Annabi, N., Najafabadi, A. H., Khademhosseini, A., & Juncker, D. (2014). Composite living fibers for creating tissue constructs using textile techniques. Advanced Functional Materials, 24(26), 4060-4067. https://doi.org/10.1002/adfm.201303655

Composite living fibers for creating tissue constructs using textile techniques. / Akbari, Mohsen; Tamayol, Ali; Laforte, Veronique; Annabi, Nasim; Najafabadi, Alireza Hassani; Khademhosseini, Ali; Juncker, David.

In: Advanced Functional Materials, Vol. 24, No. 26, 09.07.2014, p. 4060-4067.

Research output: Contribution to journalArticle

Akbari, M, Tamayol, A, Laforte, V, Annabi, N, Najafabadi, AH, Khademhosseini, A & Juncker, D 2014, 'Composite living fibers for creating tissue constructs using textile techniques', Advanced Functional Materials, vol. 24, no. 26, pp. 4060-4067. https://doi.org/10.1002/adfm.201303655
Akbari, Mohsen ; Tamayol, Ali ; Laforte, Veronique ; Annabi, Nasim ; Najafabadi, Alireza Hassani ; Khademhosseini, Ali ; Juncker, David. / Composite living fibers for creating tissue constructs using textile techniques. In: Advanced Functional Materials. 2014 ; Vol. 24, No. 26. pp. 4060-4067.
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