Competitive NMDA receptor blockers reduce striatal glutamate accumulation in ischaemia

Othman Ghribi, Jacques Callebert, Michel Plotkine, Roger G. Boulu

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Our previous studies have shown that kynurenic acid, a broad-spectrum antagonist of excitatory amino acid receptors, depressed the ischaemia-induced accumulation of glutamate and aspartate in rat striatum. In the present experiments we examined the effect of two competitive N-methyl-D-aspartate (NMDA) receptor antagonists on striatal extracellular glutamate concentrations induced by a 30 min ‘4-vessel occlusion’ ischaemia in rats. Local perfusion with 2-amino-5-phosphonovalerate (AP5; 300,μM) and with 2-amino-7-phosphonoheptanoate (AP7; 300 μM), using a microdialysis fibre markedly reduced the ischaemia-induced increase in glutamate concentrations. These results indicate that, during forebrain ischaemia the NMDA receptor type mediates glutamate and aspartate accumulation in rat striatum.

Original languageEnglish (US)
Pages (from-to)1253-1255
Number of pages3
JournalNeuroReport
Volume5
Issue number10
DOIs
StatePublished - Jun 1994

Fingerprint

Corpus Striatum
N-Methyl-D-Aspartate Receptors
Glutamic Acid
Ischemia
Aspartic Acid
Kynurenic Acid
2-Amino-5-phosphonovalerate
Microdialysis
Glutamate Receptors
Prosencephalon
Perfusion

Keywords

  • Aspartate
  • Forebrain ischaemia
  • Glutamate
  • NMDA receptor
  • Striatum

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Competitive NMDA receptor blockers reduce striatal glutamate accumulation in ischaemia. / Ghribi, Othman; Callebert, Jacques; Plotkine, Michel; Boulu, Roger G.

In: NeuroReport, Vol. 5, No. 10, 06.1994, p. 1253-1255.

Research output: Contribution to journalArticle

Ghribi, Othman ; Callebert, Jacques ; Plotkine, Michel ; Boulu, Roger G. / Competitive NMDA receptor blockers reduce striatal glutamate accumulation in ischaemia. In: NeuroReport. 1994 ; Vol. 5, No. 10. pp. 1253-1255.
@article{41f77a6942c44d689054b2236d51b382,
title = "Competitive NMDA receptor blockers reduce striatal glutamate accumulation in ischaemia",
abstract = "Our previous studies have shown that kynurenic acid, a broad-spectrum antagonist of excitatory amino acid receptors, depressed the ischaemia-induced accumulation of glutamate and aspartate in rat striatum. In the present experiments we examined the effect of two competitive N-methyl-D-aspartate (NMDA) receptor antagonists on striatal extracellular glutamate concentrations induced by a 30 min ‘4-vessel occlusion’ ischaemia in rats. Local perfusion with 2-amino-5-phosphonovalerate (AP5; 300,μM) and with 2-amino-7-phosphonoheptanoate (AP7; 300 μM), using a microdialysis fibre markedly reduced the ischaemia-induced increase in glutamate concentrations. These results indicate that, during forebrain ischaemia the NMDA receptor type mediates glutamate and aspartate accumulation in rat striatum.",
keywords = "Aspartate, Forebrain ischaemia, Glutamate, NMDA receptor, Striatum",
author = "Othman Ghribi and Jacques Callebert and Michel Plotkine and Boulu, {Roger G.}",
year = "1994",
month = "6",
doi = "10.1097/00001756-199406020-00024",
language = "English (US)",
volume = "5",
pages = "1253--1255",
journal = "NeuroReport",
issn = "0959-4965",
publisher = "Lippincott Williams and Wilkins",
number = "10",

}

TY - JOUR

T1 - Competitive NMDA receptor blockers reduce striatal glutamate accumulation in ischaemia

AU - Ghribi, Othman

AU - Callebert, Jacques

AU - Plotkine, Michel

AU - Boulu, Roger G.

PY - 1994/6

Y1 - 1994/6

N2 - Our previous studies have shown that kynurenic acid, a broad-spectrum antagonist of excitatory amino acid receptors, depressed the ischaemia-induced accumulation of glutamate and aspartate in rat striatum. In the present experiments we examined the effect of two competitive N-methyl-D-aspartate (NMDA) receptor antagonists on striatal extracellular glutamate concentrations induced by a 30 min ‘4-vessel occlusion’ ischaemia in rats. Local perfusion with 2-amino-5-phosphonovalerate (AP5; 300,μM) and with 2-amino-7-phosphonoheptanoate (AP7; 300 μM), using a microdialysis fibre markedly reduced the ischaemia-induced increase in glutamate concentrations. These results indicate that, during forebrain ischaemia the NMDA receptor type mediates glutamate and aspartate accumulation in rat striatum.

AB - Our previous studies have shown that kynurenic acid, a broad-spectrum antagonist of excitatory amino acid receptors, depressed the ischaemia-induced accumulation of glutamate and aspartate in rat striatum. In the present experiments we examined the effect of two competitive N-methyl-D-aspartate (NMDA) receptor antagonists on striatal extracellular glutamate concentrations induced by a 30 min ‘4-vessel occlusion’ ischaemia in rats. Local perfusion with 2-amino-5-phosphonovalerate (AP5; 300,μM) and with 2-amino-7-phosphonoheptanoate (AP7; 300 μM), using a microdialysis fibre markedly reduced the ischaemia-induced increase in glutamate concentrations. These results indicate that, during forebrain ischaemia the NMDA receptor type mediates glutamate and aspartate accumulation in rat striatum.

KW - Aspartate

KW - Forebrain ischaemia

KW - Glutamate

KW - NMDA receptor

KW - Striatum

UR - http://www.scopus.com/inward/record.url?scp=0028309450&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028309450&partnerID=8YFLogxK

U2 - 10.1097/00001756-199406020-00024

DO - 10.1097/00001756-199406020-00024

M3 - Article

C2 - 7919176

AN - SCOPUS:0028309450

VL - 5

SP - 1253

EP - 1255

JO - NeuroReport

JF - NeuroReport

SN - 0959-4965

IS - 10

ER -