Compensation by the Residual Intestine After Intestinal Resection in the Rat

II. Influence of postoperative time interval

W. R. Hanson, J. W. Osborne, John G Sharp

Research output: Contribution to journalArticle

177 Citations (Scopus)

Abstract

The sequence of events which comprise the early response of the residual intestine to 70% resection of the combined jejunum and ileum was investigated. Animals were killed at 2, 4, 6, 8, and 12 postoperative days. Marked increases in DNA synthesis expressed as disintegrations per minute per crypt, cells per crypt column, labeled cells per crypt column, thickness of intestinal wall components, and cells per villus column were apparent as early as 2 to 4 postoperative days. By 12 days, the values had reached the 30-day postoperative levels found in earlier experiments, indicating that a new steady state had already been reached. Jejunal and ileal crypts responded nearly the same during the first 12 days with their sizes increasing to about 150% of control values. However, although jejunal villus cell counts increased to 125% of controls, the ileal villus cell counts increased to 180% of controls, indicating that the sizes of the two crypt and villus epithelial cell populations are independently controlled.

Original languageEnglish (US)
Pages (from-to)701-705
Number of pages5
JournalGastroenterology
Volume72
Issue number4
DOIs
StatePublished - Jan 1 1977

Fingerprint

Intestines
Cell Count
Cellular Structures
Jejunum
Ileum
Cell Wall
Epithelial Cells
DNA
Population

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Compensation by the Residual Intestine After Intestinal Resection in the Rat : II. Influence of postoperative time interval. / Hanson, W. R.; Osborne, J. W.; Sharp, John G.

In: Gastroenterology, Vol. 72, No. 4, 01.01.1977, p. 701-705.

Research output: Contribution to journalArticle

@article{55932f8e691e45e091e2a9a4bedad6f3,
title = "Compensation by the Residual Intestine After Intestinal Resection in the Rat: II. Influence of postoperative time interval",
abstract = "The sequence of events which comprise the early response of the residual intestine to 70{\%} resection of the combined jejunum and ileum was investigated. Animals were killed at 2, 4, 6, 8, and 12 postoperative days. Marked increases in DNA synthesis expressed as disintegrations per minute per crypt, cells per crypt column, labeled cells per crypt column, thickness of intestinal wall components, and cells per villus column were apparent as early as 2 to 4 postoperative days. By 12 days, the values had reached the 30-day postoperative levels found in earlier experiments, indicating that a new steady state had already been reached. Jejunal and ileal crypts responded nearly the same during the first 12 days with their sizes increasing to about 150{\%} of control values. However, although jejunal villus cell counts increased to 125{\%} of controls, the ileal villus cell counts increased to 180{\%} of controls, indicating that the sizes of the two crypt and villus epithelial cell populations are independently controlled.",
author = "Hanson, {W. R.} and Osborne, {J. W.} and Sharp, {John G}",
year = "1977",
month = "1",
day = "1",
doi = "10.1016/S0016-5085(77)80157-1",
language = "English (US)",
volume = "72",
pages = "701--705",
journal = "Gastroenterology",
issn = "0016-5085",
publisher = "W.B. Saunders Ltd",
number = "4",

}

TY - JOUR

T1 - Compensation by the Residual Intestine After Intestinal Resection in the Rat

T2 - II. Influence of postoperative time interval

AU - Hanson, W. R.

AU - Osborne, J. W.

AU - Sharp, John G

PY - 1977/1/1

Y1 - 1977/1/1

N2 - The sequence of events which comprise the early response of the residual intestine to 70% resection of the combined jejunum and ileum was investigated. Animals were killed at 2, 4, 6, 8, and 12 postoperative days. Marked increases in DNA synthesis expressed as disintegrations per minute per crypt, cells per crypt column, labeled cells per crypt column, thickness of intestinal wall components, and cells per villus column were apparent as early as 2 to 4 postoperative days. By 12 days, the values had reached the 30-day postoperative levels found in earlier experiments, indicating that a new steady state had already been reached. Jejunal and ileal crypts responded nearly the same during the first 12 days with their sizes increasing to about 150% of control values. However, although jejunal villus cell counts increased to 125% of controls, the ileal villus cell counts increased to 180% of controls, indicating that the sizes of the two crypt and villus epithelial cell populations are independently controlled.

AB - The sequence of events which comprise the early response of the residual intestine to 70% resection of the combined jejunum and ileum was investigated. Animals were killed at 2, 4, 6, 8, and 12 postoperative days. Marked increases in DNA synthesis expressed as disintegrations per minute per crypt, cells per crypt column, labeled cells per crypt column, thickness of intestinal wall components, and cells per villus column were apparent as early as 2 to 4 postoperative days. By 12 days, the values had reached the 30-day postoperative levels found in earlier experiments, indicating that a new steady state had already been reached. Jejunal and ileal crypts responded nearly the same during the first 12 days with their sizes increasing to about 150% of control values. However, although jejunal villus cell counts increased to 125% of controls, the ileal villus cell counts increased to 180% of controls, indicating that the sizes of the two crypt and villus epithelial cell populations are independently controlled.

UR - http://www.scopus.com/inward/record.url?scp=0017380956&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017380956&partnerID=8YFLogxK

U2 - 10.1016/S0016-5085(77)80157-1

DO - 10.1016/S0016-5085(77)80157-1

M3 - Article

VL - 72

SP - 701

EP - 705

JO - Gastroenterology

JF - Gastroenterology

SN - 0016-5085

IS - 4

ER -