Comparison of the pulmonary lymphatic and hemodynamic changes of near- drowning in a sheep model

G. B.M. Gbaanador, J. C. Stothert, J. O. Basadre, L. Traber, H. A. Linares, D. L. Traber

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The hemodynamic and lung lymph changes following near-drowning (ND) were studied in sheep. Experimental ND was by transtracheal aspiration of 10 ml/kg body weight of either seawater (SW) or freshwater (FW). Extravascular lung water and lung lymph protein flux were significantly increased, but cardiac index was depressed in both groups following ND. Systemic and pulmonary vascular resistances were markedly elevated with FW compared to only a slight rise with SW. Lung lymph oncotic pressure decreased with SW ND from baseline of 9.7 ± 0.4 to 6.8 ± 0.63 mm Hg (P < 0.05). In contrast, FW ND increased lung lymph oncotic pressure from 12.8 ± 0.9 to 16.6 ± 1.3 mm Hg (P < 0.05). These data suggest that the changes in lung lymph and hemodynamic response to SW and FW ND differ in sheep. The changes are immediate and profound with SW, but slower in onset and less severe with FW. FW ND is associated with hemolysis, which is absent in SW ND.

Original languageEnglish (US)
Pages (from-to)245-252
Number of pages8
JournalCirculatory Shock
Volume38
Issue number4
StatePublished - Jan 1 1992

Fingerprint

Near Drowning
Sheep
Seawater
Hemodynamics
Fresh Water
Lymph
Lung
Vascular Resistance
Extravascular Lung Water
Pressure
Hemolysis
Body Weight

Keywords

  • aspiration
  • chronic sheep lymph fistula
  • freshwater near-drowning
  • hemodynamic response
  • seawater near-drowning

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Gbaanador, G. B. M., Stothert, J. C., Basadre, J. O., Traber, L., Linares, H. A., & Traber, D. L. (1992). Comparison of the pulmonary lymphatic and hemodynamic changes of near- drowning in a sheep model. Circulatory Shock, 38(4), 245-252.

Comparison of the pulmonary lymphatic and hemodynamic changes of near- drowning in a sheep model. / Gbaanador, G. B.M.; Stothert, J. C.; Basadre, J. O.; Traber, L.; Linares, H. A.; Traber, D. L.

In: Circulatory Shock, Vol. 38, No. 4, 01.01.1992, p. 245-252.

Research output: Contribution to journalArticle

Gbaanador, GBM, Stothert, JC, Basadre, JO, Traber, L, Linares, HA & Traber, DL 1992, 'Comparison of the pulmonary lymphatic and hemodynamic changes of near- drowning in a sheep model', Circulatory Shock, vol. 38, no. 4, pp. 245-252.
Gbaanador GBM, Stothert JC, Basadre JO, Traber L, Linares HA, Traber DL. Comparison of the pulmonary lymphatic and hemodynamic changes of near- drowning in a sheep model. Circulatory Shock. 1992 Jan 1;38(4):245-252.
Gbaanador, G. B.M. ; Stothert, J. C. ; Basadre, J. O. ; Traber, L. ; Linares, H. A. ; Traber, D. L. / Comparison of the pulmonary lymphatic and hemodynamic changes of near- drowning in a sheep model. In: Circulatory Shock. 1992 ; Vol. 38, No. 4. pp. 245-252.
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