Comparison of local anesthetic-cyclodextrin non-covalent complexes using capillary electrophoresis and electrospray ionization mass spectrometry

Yazen Al-Nouti, Michael G. Bartlett

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14 Citations (Scopus)

Abstract

Non-covalent complexes between three derivitized cyclodextrins (CD's) and six local anesthetics were studied using capillary electrophoresis (CE) and electrospray ionization mass spectrometry (ESI-MS). The CE study was performed using the complete filling technique (CFT). A comparison between the migration data from CE and ESI-MS inclusion complex peak abundances was made representing the association between local anesthetics and CD's in the solution and the gas phase, respectively. The results from this study showed comparable behavior of the complexes in the CE and mass spectrometer, indicating similarity in the parameters controlling the stability of these complexes. Therefore, the formation of specific non-covalent complexes, as shown in this study, could be used to predict the behavior of a complexing agent with a substrate in the solution phase by observing data obtained from ESI-MS.

Original languageEnglish (US)
Pages (from-to)928-935
Number of pages8
JournalJournal of the American Society for Mass Spectrometry
Volume13
Issue number8
DOIs
StatePublished - Aug 1 2002

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Capillary electrophoresis
Electrospray ionization
Electrospray Ionization Mass Spectrometry
Cyclodextrins
Capillary Electrophoresis
Local Anesthetics
Mass spectrometry
Mass spectrometers
Gases
Association reactions
Substrates

ASJC Scopus subject areas

  • Structural Biology
  • Spectroscopy

Cite this

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abstract = "Non-covalent complexes between three derivitized cyclodextrins (CD's) and six local anesthetics were studied using capillary electrophoresis (CE) and electrospray ionization mass spectrometry (ESI-MS). The CE study was performed using the complete filling technique (CFT). A comparison between the migration data from CE and ESI-MS inclusion complex peak abundances was made representing the association between local anesthetics and CD's in the solution and the gas phase, respectively. The results from this study showed comparable behavior of the complexes in the CE and mass spectrometer, indicating similarity in the parameters controlling the stability of these complexes. Therefore, the formation of specific non-covalent complexes, as shown in this study, could be used to predict the behavior of a complexing agent with a substrate in the solution phase by observing data obtained from ESI-MS.",
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