Comparison of local anesthetic-cyclodextrin non-covalent complexes using capillary electrophoresis and electrospray ionization mass spectrometry

Yazen Al-Nouti, Michael G. Bartlett

Research output: Contribution to conferencePaper

Abstract

Using capillary electrophoresis and electrospray ionization mass spectrometry local anesthetic-cyclodextrin non-covalent complexes were compared. The separation of six local anesthetics, proparacaine, meprilcaine, lidocaine, prilocaine, dibucaine and dyclonine using three different cyclodextrins were studied. To determine the stability of the complexes in the gas phase using ESI_MS, the fraction of cyclodextrin (CD) complexed with each analyte was calculated. The association strengths order of the local anesthetics with all the CD's was dyclonine > dibucaine > meprilcaine > prilocaine > lidocaine > proparacaine.

Original languageEnglish (US)
Pages457-458
Number of pages2
StatePublished - Dec 1 2002
EventProceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics - Orlando, FL, United States
Duration: Jun 2 2002Jun 6 2002

Conference

ConferenceProceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics
CountryUnited States
CityOrlando, FL
Period6/2/026/6/02

Fingerprint

Capillary electrophoresis
Electrospray ionization
Cyclodextrins
Local Anesthetics
Dibucaine
Prilocaine
Mass spectrometry
Lidocaine
Gases
Association reactions
proxymetacaine
dyclonine

ASJC Scopus subject areas

  • Spectroscopy

Cite this

Al-Nouti, Y., & Bartlett, M. G. (2002). Comparison of local anesthetic-cyclodextrin non-covalent complexes using capillary electrophoresis and electrospray ionization mass spectrometry. 457-458. Paper presented at Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL, United States.

Comparison of local anesthetic-cyclodextrin non-covalent complexes using capillary electrophoresis and electrospray ionization mass spectrometry. / Al-Nouti, Yazen; Bartlett, Michael G.

2002. 457-458 Paper presented at Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL, United States.

Research output: Contribution to conferencePaper

Al-Nouti, Y & Bartlett, MG 2002, 'Comparison of local anesthetic-cyclodextrin non-covalent complexes using capillary electrophoresis and electrospray ionization mass spectrometry', Paper presented at Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL, United States, 6/2/02 - 6/6/02 pp. 457-458.
Al-Nouti Y, Bartlett MG. Comparison of local anesthetic-cyclodextrin non-covalent complexes using capillary electrophoresis and electrospray ionization mass spectrometry. 2002. Paper presented at Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL, United States.
Al-Nouti, Yazen ; Bartlett, Michael G. / Comparison of local anesthetic-cyclodextrin non-covalent complexes using capillary electrophoresis and electrospray ionization mass spectrometry. Paper presented at Proceedings - 50th ASMS Conference on Mass Spectrometry and Allied Topics, Orlando, FL, United States.2 p.
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