Comparison of inflammatory infiltrates in trigeminal ganglia of cattle infected with wild-type Bovine herpesvirus 1 versus a virus strain containing a mutation in the LR (latency-related) gene

Sandra Perez, Luciane Lovato, You Zhou, Alan R Doster, Clinton Jones

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

During latency, the bovine herpesvirus 1 (BHV-1) latency-related (LR) RNA is abundantly expressed in neurons within trigeminal ganglia (TG). A LR mutant virus that does not express two LR proteins is unable to reactivate from latency following dexamethasone treatment. Increased infiltration of inflammatory cells occurs in TG of calves acutely infected with the LR mutant virus. Throughout acute infection, wild-type BHV-1 DNA is detected in neurons surrounded by mononuclear infiltrates and in non-neuronal cells comprising the infiltrate. Conversely, LR mutant DNA is only detected in neurons near the end of acute infection, suggesting LR gene products promote virus spread in TG.

Original languageEnglish (US)
Pages (from-to)392-397
Number of pages6
JournalJournal of neurovirology
Volume12
Issue number5
DOIs
Publication statusPublished - Oct 1 2006

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Keywords

  • Bovine herpesvirus 1 (BHV-1)
  • Infiltrating lymphocytes
  • Latency
  • Trigeminal ganglia

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Virology

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