Comparison of autologous and allogeneic hematopoietic stem cell transplantation for follicular lymphoma

Koen Van Besien, Fausto R. Loberiza, Ruta Bajorunaite, James O. Armitage, Asad Bashey, Linda J. Burns, Cesar O. Freytes, John Gibson, Mary M. Horowitz, David J. Inwards, David I. Marks, Rodrigo Martino, Richard T. Maziarz, Arturo Molina, Santiago Pavlovsky, Andrew L. Pecora, Harry C. Schouten, Thomas C. Shea, Hillard M. Lazarus, J. Douglas RizzoJulie M. Vose

Research output: Contribution to journalArticle

294 Citations (Scopus)

Abstract

In this article, we report on 904 patients undergoing transplantation for follicular lymphoma. A total of 176 (19%) received allogeneic, 131 (14%) received purged autologous, and 597 (67%) received unpurged autologous transplants. Five-year treatment-related mortality (TRM) rates were 30%, 14%, and 8% and 5-year recurrence rates were 21%, 43%, and 58% after allotransplantation, purged autotransplantation, and unpurged autotransplantation, respectively. In multivariate analyses, allotransplantation had higher TRM and lower disease recurrence. Purged autotransplantation had a 26% lower recurrence risk than unpurged autotransplantation. Five-year probabilities of survival were 51%, 62%, and 55% after allogeneic, purged autotransplantation, and unpurged autotransplantation, respectively. Advanced age, prolonged interval from diagnosis to transplantation, high lactate dehydrogenase (LDH), refractory disease, bone marrow involvement, low performance scores, and transplantation between 1990 and 1993 were associated with adverse outcomes. Total body irradiation was associated with higher TRM but lower recurrence. There was no association between acute or chronic graft-versus-host disease and recurrence after allotransplantation. We conclude that both allogeneic and autologous transplantation can induce durable remissions. There may be a benefit to graft purging in autologous transplantation. The decreased recurrence after allotransplantation is offset by increased TRM. We did not detect a correlation between graft-versus-host disease (GVHD) and recurrence. Finally, outcomes of transplantation for follicular lymphoma show improvement over the past decade.

Original languageEnglish (US)
Pages (from-to)3521-3529
Number of pages9
JournalBlood
Volume102
Issue number10
DOIs
StatePublished - Nov 15 2003

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Follicular Lymphoma
Autologous Transplantation
Hematopoietic Stem Cell Transplantation
Stem cells
Grafts
Recurrence
Transplantation
Transplantation (surgical)
Purging
Mortality
Autografts
Graft vs Host Disease
L-Lactate Dehydrogenase
Refractory materials
Bone
Bone Marrow Diseases
Irradiation
Whole-Body Irradiation
Homologous Transplantation
Therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Cite this

Comparison of autologous and allogeneic hematopoietic stem cell transplantation for follicular lymphoma. / Van Besien, Koen; Loberiza, Fausto R.; Bajorunaite, Ruta; Armitage, James O.; Bashey, Asad; Burns, Linda J.; Freytes, Cesar O.; Gibson, John; Horowitz, Mary M.; Inwards, David J.; Marks, David I.; Martino, Rodrigo; Maziarz, Richard T.; Molina, Arturo; Pavlovsky, Santiago; Pecora, Andrew L.; Schouten, Harry C.; Shea, Thomas C.; Lazarus, Hillard M.; Rizzo, J. Douglas; Vose, Julie M.

In: Blood, Vol. 102, No. 10, 15.11.2003, p. 3521-3529.

Research output: Contribution to journalArticle

Van Besien, K, Loberiza, FR, Bajorunaite, R, Armitage, JO, Bashey, A, Burns, LJ, Freytes, CO, Gibson, J, Horowitz, MM, Inwards, DJ, Marks, DI, Martino, R, Maziarz, RT, Molina, A, Pavlovsky, S, Pecora, AL, Schouten, HC, Shea, TC, Lazarus, HM, Rizzo, JD & Vose, JM 2003, 'Comparison of autologous and allogeneic hematopoietic stem cell transplantation for follicular lymphoma', Blood, vol. 102, no. 10, pp. 3521-3529. https://doi.org/10.1182/blood-2003-04-1205
Van Besien, Koen ; Loberiza, Fausto R. ; Bajorunaite, Ruta ; Armitage, James O. ; Bashey, Asad ; Burns, Linda J. ; Freytes, Cesar O. ; Gibson, John ; Horowitz, Mary M. ; Inwards, David J. ; Marks, David I. ; Martino, Rodrigo ; Maziarz, Richard T. ; Molina, Arturo ; Pavlovsky, Santiago ; Pecora, Andrew L. ; Schouten, Harry C. ; Shea, Thomas C. ; Lazarus, Hillard M. ; Rizzo, J. Douglas ; Vose, Julie M. / Comparison of autologous and allogeneic hematopoietic stem cell transplantation for follicular lymphoma. In: Blood. 2003 ; Vol. 102, No. 10. pp. 3521-3529.
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abstract = "In this article, we report on 904 patients undergoing transplantation for follicular lymphoma. A total of 176 (19{\%}) received allogeneic, 131 (14{\%}) received purged autologous, and 597 (67{\%}) received unpurged autologous transplants. Five-year treatment-related mortality (TRM) rates were 30{\%}, 14{\%}, and 8{\%} and 5-year recurrence rates were 21{\%}, 43{\%}, and 58{\%} after allotransplantation, purged autotransplantation, and unpurged autotransplantation, respectively. In multivariate analyses, allotransplantation had higher TRM and lower disease recurrence. Purged autotransplantation had a 26{\%} lower recurrence risk than unpurged autotransplantation. Five-year probabilities of survival were 51{\%}, 62{\%}, and 55{\%} after allogeneic, purged autotransplantation, and unpurged autotransplantation, respectively. Advanced age, prolonged interval from diagnosis to transplantation, high lactate dehydrogenase (LDH), refractory disease, bone marrow involvement, low performance scores, and transplantation between 1990 and 1993 were associated with adverse outcomes. Total body irradiation was associated with higher TRM but lower recurrence. There was no association between acute or chronic graft-versus-host disease and recurrence after allotransplantation. We conclude that both allogeneic and autologous transplantation can induce durable remissions. There may be a benefit to graft purging in autologous transplantation. The decreased recurrence after allotransplantation is offset by increased TRM. We did not detect a correlation between graft-versus-host disease (GVHD) and recurrence. Finally, outcomes of transplantation for follicular lymphoma show improvement over the past decade.",
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T1 - Comparison of autologous and allogeneic hematopoietic stem cell transplantation for follicular lymphoma

AU - Van Besien, Koen

AU - Loberiza, Fausto R.

AU - Bajorunaite, Ruta

AU - Armitage, James O.

AU - Bashey, Asad

AU - Burns, Linda J.

AU - Freytes, Cesar O.

AU - Gibson, John

AU - Horowitz, Mary M.

AU - Inwards, David J.

AU - Marks, David I.

AU - Martino, Rodrigo

AU - Maziarz, Richard T.

AU - Molina, Arturo

AU - Pavlovsky, Santiago

AU - Pecora, Andrew L.

AU - Schouten, Harry C.

AU - Shea, Thomas C.

AU - Lazarus, Hillard M.

AU - Rizzo, J. Douglas

AU - Vose, Julie M.

PY - 2003/11/15

Y1 - 2003/11/15

N2 - In this article, we report on 904 patients undergoing transplantation for follicular lymphoma. A total of 176 (19%) received allogeneic, 131 (14%) received purged autologous, and 597 (67%) received unpurged autologous transplants. Five-year treatment-related mortality (TRM) rates were 30%, 14%, and 8% and 5-year recurrence rates were 21%, 43%, and 58% after allotransplantation, purged autotransplantation, and unpurged autotransplantation, respectively. In multivariate analyses, allotransplantation had higher TRM and lower disease recurrence. Purged autotransplantation had a 26% lower recurrence risk than unpurged autotransplantation. Five-year probabilities of survival were 51%, 62%, and 55% after allogeneic, purged autotransplantation, and unpurged autotransplantation, respectively. Advanced age, prolonged interval from diagnosis to transplantation, high lactate dehydrogenase (LDH), refractory disease, bone marrow involvement, low performance scores, and transplantation between 1990 and 1993 were associated with adverse outcomes. Total body irradiation was associated with higher TRM but lower recurrence. There was no association between acute or chronic graft-versus-host disease and recurrence after allotransplantation. We conclude that both allogeneic and autologous transplantation can induce durable remissions. There may be a benefit to graft purging in autologous transplantation. The decreased recurrence after allotransplantation is offset by increased TRM. We did not detect a correlation between graft-versus-host disease (GVHD) and recurrence. Finally, outcomes of transplantation for follicular lymphoma show improvement over the past decade.

AB - In this article, we report on 904 patients undergoing transplantation for follicular lymphoma. A total of 176 (19%) received allogeneic, 131 (14%) received purged autologous, and 597 (67%) received unpurged autologous transplants. Five-year treatment-related mortality (TRM) rates were 30%, 14%, and 8% and 5-year recurrence rates were 21%, 43%, and 58% after allotransplantation, purged autotransplantation, and unpurged autotransplantation, respectively. In multivariate analyses, allotransplantation had higher TRM and lower disease recurrence. Purged autotransplantation had a 26% lower recurrence risk than unpurged autotransplantation. Five-year probabilities of survival were 51%, 62%, and 55% after allogeneic, purged autotransplantation, and unpurged autotransplantation, respectively. Advanced age, prolonged interval from diagnosis to transplantation, high lactate dehydrogenase (LDH), refractory disease, bone marrow involvement, low performance scores, and transplantation between 1990 and 1993 were associated with adverse outcomes. Total body irradiation was associated with higher TRM but lower recurrence. There was no association between acute or chronic graft-versus-host disease and recurrence after allotransplantation. We conclude that both allogeneic and autologous transplantation can induce durable remissions. There may be a benefit to graft purging in autologous transplantation. The decreased recurrence after allotransplantation is offset by increased TRM. We did not detect a correlation between graft-versus-host disease (GVHD) and recurrence. Finally, outcomes of transplantation for follicular lymphoma show improvement over the past decade.

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