Comparison of a rapid hepatitis B immunization schedule to the standard schedule for adults

Luis S. Marsano, Richard N. Greenberg, Robert B. Kirkpatrick, Rowen K. Zetterman, Abigail Christiansen, Daniel J. Smith, Maria D. DeMedina, Eugene R. Schiff

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

We report a prospective, randomized, single-blinded trial comparing immunogenicity of rapid (0, 1, and 2 months) versus standard schedule (0, 1, 6 months) hepatitis B vaccinations of healthy adults with recombinant hepatitis B vaccine (Engerix-B, 20 μg i.m.) Volunteers (230 of 234) negative to hepatitis B were randomized and completed the study. Groups were similar in age, weight, race, and obesity rate, but the rapid schedule group had more women. Both groups reached ≥100 mIU/mL at a similar rate, but a higher seroprotection rate at ≥500 mIU/mL was reached by the standard schedule. No demographic variables influenced the effect of dose schedule on anti- hepatitis B titer. We conclude that rapid schedule vaccination gives a rate that is quicker than, and identical to, the rate of seroprotection of the standard schedule vaccination.

Original languageEnglish (US)
Pages (from-to)111-115
Number of pages5
JournalAmerican Journal of Gastroenterology
Volume91
Issue number1
StatePublished - Jan 1 1996

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Immunization Schedule
Hepatitis B
Appointments and Schedules
Vaccination
Hepatitis B Vaccines
Synthetic Vaccines
Volunteers
Obesity
Demography
Weights and Measures

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Marsano, L. S., Greenberg, R. N., Kirkpatrick, R. B., Zetterman, R. K., Christiansen, A., Smith, D. J., ... Schiff, E. R. (1996). Comparison of a rapid hepatitis B immunization schedule to the standard schedule for adults. American Journal of Gastroenterology, 91(1), 111-115.

Comparison of a rapid hepatitis B immunization schedule to the standard schedule for adults. / Marsano, Luis S.; Greenberg, Richard N.; Kirkpatrick, Robert B.; Zetterman, Rowen K.; Christiansen, Abigail; Smith, Daniel J.; DeMedina, Maria D.; Schiff, Eugene R.

In: American Journal of Gastroenterology, Vol. 91, No. 1, 01.01.1996, p. 111-115.

Research output: Contribution to journalArticle

Marsano, LS, Greenberg, RN, Kirkpatrick, RB, Zetterman, RK, Christiansen, A, Smith, DJ, DeMedina, MD & Schiff, ER 1996, 'Comparison of a rapid hepatitis B immunization schedule to the standard schedule for adults', American Journal of Gastroenterology, vol. 91, no. 1, pp. 111-115.
Marsano LS, Greenberg RN, Kirkpatrick RB, Zetterman RK, Christiansen A, Smith DJ et al. Comparison of a rapid hepatitis B immunization schedule to the standard schedule for adults. American Journal of Gastroenterology. 1996 Jan 1;91(1):111-115.
Marsano, Luis S. ; Greenberg, Richard N. ; Kirkpatrick, Robert B. ; Zetterman, Rowen K. ; Christiansen, Abigail ; Smith, Daniel J. ; DeMedina, Maria D. ; Schiff, Eugene R. / Comparison of a rapid hepatitis B immunization schedule to the standard schedule for adults. In: American Journal of Gastroenterology. 1996 ; Vol. 91, No. 1. pp. 111-115.
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