Comparative subchronic oral toxicity of sulphite and acetaldehyde hydroxysulphonate in rats

J. Y. Hui, J. T. Beery, N. A. Higley, Stephen L Taylor

Research output: Contribution to journalArticle

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Abstract

A subchronic oral toxicity study of sodium metabisulphite and acetaldehyde hydroxysulphonate was conducted in normal and sulphite oxidase-deficient rats. At the highest dose level (350 mg SO2 equiv./kg body weight/day for 3 wk followed by 175 mg SO2 equiv./kg body weight/day for 5 wk of either compound), gastric lesions were noted histologically in both normal and sulphite oxidase-deficient rats. The lesions were more severe and more frequently encountered in the sulphite oxidase-deficient rats. The no-effect level for Na2S2O5 was 70 mg SO2 equiv./kg body weight/day in both normal and sulphite oxidase-deficient rats. Liver lesions were noted in rats treated with acetaldehyde hydroxysulphonate. These lesions may possibly be attributable to the effects of free acetaldehyde. The no-effect level for acetaldehyde hydroxysulphonate was 7 mg SO2 equiv./kg body weight/day for sulphite oxidase-deficient rats and 70 mg SO2 equiv./kg body weight/day for normal rats. Increased urinary excretion of sulphite was noted in sulphite oxidase-deficient rats whether or not they were given exogenous sulphites. An increase in urinary sulphite levels in sulphite oxidase-deficient rats was observed after dosing with acetaldehyde hydroxysulphonate. These findings suggest that acetaldehyde hydroxysulphonate is metabolized to acetaldehyde and free sulphite.

Original languageEnglish (US)
Pages (from-to)349-359
Number of pages11
JournalFood and Chemical Toxicology
Volume27
Issue number6
DOIs
StatePublished - Jan 1 1989

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Sulfite Oxidase
Sulfites
sulfite oxidase
sulfites
acetaldehyde
Toxicity
Rats
rats
lesions (animal)
body weight
Body Weight
Acetaldehyde
sodium metabisulfite
acetaldehyde hydroxysulfonate
Ideal Body Weight
toxicity testing
Liver
Stomach
stomach
excretion

ASJC Scopus subject areas

  • Food Science
  • Toxicology

Cite this

Comparative subchronic oral toxicity of sulphite and acetaldehyde hydroxysulphonate in rats. / Hui, J. Y.; Beery, J. T.; Higley, N. A.; Taylor, Stephen L.

In: Food and Chemical Toxicology, Vol. 27, No. 6, 01.01.1989, p. 349-359.

Research output: Contribution to journalArticle

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