Comparative manufacture and cell-based delivery of antiretroviral nanoformulations.

Shantanu Balkundi, Ari S. Nowacek, Ram S. Veerubhotla, Han Chen, Andrea Martinez-Skinner, Upal Roy, R Lee Mosley, Georgette D Kanmogne, Xinming Liu, Alexander V. Kabanov, Tatiana K Bronich, JoEllyn M McMillan, Howard Eliot Gendelman

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Nanoformulations of crystalline indinavir, ritonavir, atazanavir, and efavirenz were manufactured by wet milling, homogenization or sonication with a variety of excipients. The chemical, biological, immune, virological, and toxicological properties of these formulations were compared using an established monocyte-derived macrophage scoring indicator system. Measurements of drug uptake, retention, release, and antiretroviral activity demonstrated differences amongst preparation methods. Interestingly, for drug cell targeting and antiretroviral responses the most significant difference among the particles was the drug itself. We posit that the choice of drug and formulation composition may ultimately affect clinical utility.

Original languageEnglish (US)
Pages (from-to)3393-3404
Number of pages12
JournalInternational journal of nanomedicine
Volume6
StatePublished - Jan 1 2011

Fingerprint

Sonication
Macrophages
efavirenz
Indinavir
Crystalline materials
Ritonavir
Drug Compounding
Excipients
Drug Delivery Systems
Chemical analysis
Pharmaceutical Preparations
Toxicology
Atazanavir Sulfate

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

Cite this

Balkundi, S., Nowacek, A. S., Veerubhotla, R. S., Chen, H., Martinez-Skinner, A., Roy, U., ... Gendelman, H. E. (2011). Comparative manufacture and cell-based delivery of antiretroviral nanoformulations. International journal of nanomedicine, 6, 3393-3404.

Comparative manufacture and cell-based delivery of antiretroviral nanoformulations. / Balkundi, Shantanu; Nowacek, Ari S.; Veerubhotla, Ram S.; Chen, Han; Martinez-Skinner, Andrea; Roy, Upal; Mosley, R Lee; Kanmogne, Georgette D; Liu, Xinming; Kabanov, Alexander V.; Bronich, Tatiana K; McMillan, JoEllyn M; Gendelman, Howard Eliot.

In: International journal of nanomedicine, Vol. 6, 01.01.2011, p. 3393-3404.

Research output: Contribution to journalArticle

Balkundi, S, Nowacek, AS, Veerubhotla, RS, Chen, H, Martinez-Skinner, A, Roy, U, Mosley, RL, Kanmogne, GD, Liu, X, Kabanov, AV, Bronich, TK, McMillan, JM & Gendelman, HE 2011, 'Comparative manufacture and cell-based delivery of antiretroviral nanoformulations.', International journal of nanomedicine, vol. 6, pp. 3393-3404.
Balkundi S, Nowacek AS, Veerubhotla RS, Chen H, Martinez-Skinner A, Roy U et al. Comparative manufacture and cell-based delivery of antiretroviral nanoformulations. International journal of nanomedicine. 2011 Jan 1;6:3393-3404.
Balkundi, Shantanu ; Nowacek, Ari S. ; Veerubhotla, Ram S. ; Chen, Han ; Martinez-Skinner, Andrea ; Roy, Upal ; Mosley, R Lee ; Kanmogne, Georgette D ; Liu, Xinming ; Kabanov, Alexander V. ; Bronich, Tatiana K ; McMillan, JoEllyn M ; Gendelman, Howard Eliot. / Comparative manufacture and cell-based delivery of antiretroviral nanoformulations. In: International journal of nanomedicine. 2011 ; Vol. 6. pp. 3393-3404.
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