Comparative clinical pharmacology of cisplatin and carboplatin

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The platinum compounds cisplatin and carboplatin are active against a wide range of adult and pediatric malignancies. Whereas both exert their cytotoxic effect by incorporating into DNA, they have substantially different systemic and cellular pharmacology. In addition, their toxicity profiles are much different. Substantial interpatient pharmacokinetic variability and narrow therapeutic indexes of the two agents led to the development of several dosing strategies. Although these strategies reduce pharmacokinetic variability, their effect on improving patient outcome remains to be determined.

Original languageEnglish (US)
Pages (from-to)140S-145S
JournalPharmacotherapy
Volume17
Issue number5 II SUPPL.
StatePublished - Sep 1 1997

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Clinical Pharmacology
Carboplatin
Cisplatin
Pharmacokinetics
Platinum Compounds
Pharmacology
Pediatrics
DNA
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Comparative clinical pharmacology of cisplatin and carboplatin. / Murry, Daryl J.

In: Pharmacotherapy, Vol. 17, No. 5 II SUPPL., 01.09.1997, p. 140S-145S.

Research output: Contribution to journalArticle

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