Comparative Carcinogenicity in Swiss Mice of N-[4-(5-Nitro-2-furyl)-2-thiazolyl]acetamide and Structurally Related 5-Nitrofurans and 4-Nitrobenzenes

Samuel Monroe Cohen, G. M. Lower, E. Ertürk, G. T. Bryan

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Abstract

N-[4-(5-Nitro-2-fury1)-2-thiazolyl] acetamide (NFTA), fed to female Swiss mice at doses of 0.05 and 0.1% of the diet, induced a high incidence of lymphocytic leukemia and a low incidence of forestomach tumors. Several other chemicals structurally related to NFTA were also fed to female Swiss mice to determine structure-activity relationships with respect to organ specificity. N-[4-(5-Nitro-2-furyl)-2-thiazolyl] - formamide induced urinary bladder carcinomas in 20 of 21 mice and low incidences of leukemia and forestomach tumors. 2,2,2-Trifluoror-N-[4-(5-nitro-2-furyl)-2-thiazolyl] acetamide, 2-amino-4-(5-nitro-2-furyl) thiazole, N- [5–(5-nitro-2-fury 1)-1,3,4-thiadiazol-2-yl] acetamide, formic acid 2-[4-(5-nitro-2-fury1)-2-thiazoly 1 ] hydrazide, 2-(2,2-dimethylhydrazino)-4-(5-nitro-2-fury1)thiazole, and 2-hydrazino4-(5-nitro-2-furyl)thiazole induced high incidences of forestomach tumors (23 of 25, 24 of 27, 21 of 22, 12 of 20, 13 of 23, and 10 of 17, respectively). N-[4-(5-Nitro-2-furyl)-2-thiazolyl] formamide, formic acid 2-[4-(5-nitro-2-furyl)-2-thiazoly 1 ] hydrazide, 2-hydrazino-4-(p-n itrophenyl)thiazole, 2-hydrazino4-(p-aminophenyl)thiazole, and 2-amino4-(p-nitrophenyl)thiazole induced low incidences of lymphocytic leukemia (6 of 21, 10 of 20, 5 of 21, 5 of 22, and 5 of 20, respectively) with considerably longer latent periods than was the case with NFTA.

Original languageEnglish (US)
Pages (from-to)1593-1597
Number of pages5
JournalCancer Research
Volume33
Issue number7
StatePublished - Jan 1 1973

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Nitrobenzenes
Nitrofurans
Thiazoles
formic acid
Incidence
Lymphoid Leukemia
Neoplasms
Organ Specificity
Structure-Activity Relationship
Leukemia
Urinary Bladder
furothiazole
Diet
Carcinoma
acetamide

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Comparative Carcinogenicity in Swiss Mice of N-[4-(5-Nitro-2-furyl)-2-thiazolyl]acetamide and Structurally Related 5-Nitrofurans and 4-Nitrobenzenes. / Cohen, Samuel Monroe; Lower, G. M.; Ertürk, E.; Bryan, G. T.

In: Cancer Research, Vol. 33, No. 7, 01.01.1973, p. 1593-1597.

Research output: Contribution to journalArticle

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abstract = "N-[4-(5-Nitro-2-fury1)-2-thiazolyl] acetamide (NFTA), fed to female Swiss mice at doses of 0.05 and 0.1{\%} of the diet, induced a high incidence of lymphocytic leukemia and a low incidence of forestomach tumors. Several other chemicals structurally related to NFTA were also fed to female Swiss mice to determine structure-activity relationships with respect to organ specificity. N-[4-(5-Nitro-2-furyl)-2-thiazolyl] - formamide induced urinary bladder carcinomas in 20 of 21 mice and low incidences of leukemia and forestomach tumors. 2,2,2-Trifluoror-N-[4-(5-nitro-2-furyl)-2-thiazolyl] acetamide, 2-amino-4-(5-nitro-2-furyl) thiazole, N- [5–(5-nitro-2-fury 1)-1,3,4-thiadiazol-2-yl] acetamide, formic acid 2-[4-(5-nitro-2-fury1)-2-thiazoly 1 ] hydrazide, 2-(2,2-dimethylhydrazino)-4-(5-nitro-2-fury1)thiazole, and 2-hydrazino4-(5-nitro-2-furyl)thiazole induced high incidences of forestomach tumors (23 of 25, 24 of 27, 21 of 22, 12 of 20, 13 of 23, and 10 of 17, respectively). N-[4-(5-Nitro-2-furyl)-2-thiazolyl] formamide, formic acid 2-[4-(5-nitro-2-furyl)-2-thiazoly 1 ] hydrazide, 2-hydrazino-4-(p-n itrophenyl)thiazole, 2-hydrazino4-(p-aminophenyl)thiazole, and 2-amino4-(p-nitrophenyl)thiazole induced low incidences of lymphocytic leukemia (6 of 21, 10 of 20, 5 of 21, 5 of 22, and 5 of 20, respectively) with considerably longer latent periods than was the case with NFTA.",
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N2 - N-[4-(5-Nitro-2-fury1)-2-thiazolyl] acetamide (NFTA), fed to female Swiss mice at doses of 0.05 and 0.1% of the diet, induced a high incidence of lymphocytic leukemia and a low incidence of forestomach tumors. Several other chemicals structurally related to NFTA were also fed to female Swiss mice to determine structure-activity relationships with respect to organ specificity. N-[4-(5-Nitro-2-furyl)-2-thiazolyl] - formamide induced urinary bladder carcinomas in 20 of 21 mice and low incidences of leukemia and forestomach tumors. 2,2,2-Trifluoror-N-[4-(5-nitro-2-furyl)-2-thiazolyl] acetamide, 2-amino-4-(5-nitro-2-furyl) thiazole, N- [5–(5-nitro-2-fury 1)-1,3,4-thiadiazol-2-yl] acetamide, formic acid 2-[4-(5-nitro-2-fury1)-2-thiazoly 1 ] hydrazide, 2-(2,2-dimethylhydrazino)-4-(5-nitro-2-fury1)thiazole, and 2-hydrazino4-(5-nitro-2-furyl)thiazole induced high incidences of forestomach tumors (23 of 25, 24 of 27, 21 of 22, 12 of 20, 13 of 23, and 10 of 17, respectively). N-[4-(5-Nitro-2-furyl)-2-thiazolyl] formamide, formic acid 2-[4-(5-nitro-2-furyl)-2-thiazoly 1 ] hydrazide, 2-hydrazino-4-(p-n itrophenyl)thiazole, 2-hydrazino4-(p-aminophenyl)thiazole, and 2-amino4-(p-nitrophenyl)thiazole induced low incidences of lymphocytic leukemia (6 of 21, 10 of 20, 5 of 21, 5 of 22, and 5 of 20, respectively) with considerably longer latent periods than was the case with NFTA.

AB - N-[4-(5-Nitro-2-fury1)-2-thiazolyl] acetamide (NFTA), fed to female Swiss mice at doses of 0.05 and 0.1% of the diet, induced a high incidence of lymphocytic leukemia and a low incidence of forestomach tumors. Several other chemicals structurally related to NFTA were also fed to female Swiss mice to determine structure-activity relationships with respect to organ specificity. N-[4-(5-Nitro-2-furyl)-2-thiazolyl] - formamide induced urinary bladder carcinomas in 20 of 21 mice and low incidences of leukemia and forestomach tumors. 2,2,2-Trifluoror-N-[4-(5-nitro-2-furyl)-2-thiazolyl] acetamide, 2-amino-4-(5-nitro-2-furyl) thiazole, N- [5–(5-nitro-2-fury 1)-1,3,4-thiadiazol-2-yl] acetamide, formic acid 2-[4-(5-nitro-2-fury1)-2-thiazoly 1 ] hydrazide, 2-(2,2-dimethylhydrazino)-4-(5-nitro-2-fury1)thiazole, and 2-hydrazino4-(5-nitro-2-furyl)thiazole induced high incidences of forestomach tumors (23 of 25, 24 of 27, 21 of 22, 12 of 20, 13 of 23, and 10 of 17, respectively). N-[4-(5-Nitro-2-furyl)-2-thiazolyl] formamide, formic acid 2-[4-(5-nitro-2-furyl)-2-thiazoly 1 ] hydrazide, 2-hydrazino-4-(p-n itrophenyl)thiazole, 2-hydrazino4-(p-aminophenyl)thiazole, and 2-amino4-(p-nitrophenyl)thiazole induced low incidences of lymphocytic leukemia (6 of 21, 10 of 20, 5 of 21, 5 of 22, and 5 of 20, respectively) with considerably longer latent periods than was the case with NFTA.

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