Comparative antimalarial activities of six pairs of 1,2,4,5-tetraoxanes (peroxide dimers) and 1,2,4,5,7,8-hexaoxonanes (peroxide trimers)

Yuxiang Dong, Darren Creek, Jacques Chollet, Hugues Matile, Susan A. Charman, Sergio Wittlin, James K. Wood, Jonathan L. Vennerstrom

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Six tetraoxanes had 50% inhibitory concentrations in the range of 10 to 100 ng/ml against Plasmodium falciparum, whereas the corresponding hexaoxonanes had minimal antimalarial activity. The lack of iron-mediated reactivity of the hexaoxonanes may explain their low activity compared to the tetraoxanes, the latter of which are able to undergo iron (II)-mediated activation.

Original languageEnglish (US)
Pages (from-to)3033-3035
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume51
Issue number8
DOIs
StatePublished - Aug 1 2007

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Tetraoxanes
Peroxides
Antimalarials
Iron
Plasmodium falciparum
Inhibitory Concentration 50

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Comparative antimalarial activities of six pairs of 1,2,4,5-tetraoxanes (peroxide dimers) and 1,2,4,5,7,8-hexaoxonanes (peroxide trimers). / Dong, Yuxiang; Creek, Darren; Chollet, Jacques; Matile, Hugues; Charman, Susan A.; Wittlin, Sergio; Wood, James K.; Vennerstrom, Jonathan L.

In: Antimicrobial Agents and Chemotherapy, Vol. 51, No. 8, 01.08.2007, p. 3033-3035.

Research output: Contribution to journalArticle

Dong, Yuxiang ; Creek, Darren ; Chollet, Jacques ; Matile, Hugues ; Charman, Susan A. ; Wittlin, Sergio ; Wood, James K. ; Vennerstrom, Jonathan L. / Comparative antimalarial activities of six pairs of 1,2,4,5-tetraoxanes (peroxide dimers) and 1,2,4,5,7,8-hexaoxonanes (peroxide trimers). In: Antimicrobial Agents and Chemotherapy. 2007 ; Vol. 51, No. 8. pp. 3033-3035.
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