Comparative Analysis of Protein-Protein Interactions in Cancer-Associated Genes

Purnima Guda, Sridar V. Chittur, Chittibabu Guda

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Protein-protein interactions (PPIs) have been widely studied to understand the biological processes or molecular functions associated with different disease systems like cancer. While focused studies on individual cancers have generated valuable information, global and comparative analysis of datasets from different cancer types has not been done. In this work, we carried out bioinformatic analysis of PPIs corresponding to differentially expressed genes from microarrays of various tumor tissues (belonging to bladder, colon, kidney and thyroid cancers) and compared their associated biological processes and molecular functions (based on Gene Ontology terms). We identified a set of processes or functions that are common to all these cancers, as well as those that are specific to only one or partial cancer types. Similarly, protein interaction networks in nucleic acid metabolism were compared to identify the common/specific clusters of proteins across different cancer types. Our results provide a basis for further experimental investigations to study protein interaction networks associated with cancer. The methodology developed in this work can also be applied to study similar disease systems.

Original languageEnglish (US)
Pages (from-to)25-36
Number of pages12
JournalGenomics, Proteomics and Bioinformatics
Volume7
Issue number1-2
DOIs
StatePublished - Jun 1 2009
Externally publishedYes

Fingerprint

Neoplasm Genes
Protein-protein Interaction
Comparative Analysis
Cancer
Genes
Gene
Proteins
Neoplasms
Protein Interaction Maps
Biological Phenomena
Protein Interaction Networks
Nucleic acids
Gene Ontology
Bioinformatics
Microarrays
Kidney Neoplasms
Global Analysis
Metabolism
Kidney
Nucleic Acids

Keywords

  • GO similarity analysis
  • cancer bioinformatics
  • cancer-associated genes
  • protein-protein interaction

ASJC Scopus subject areas

  • Genetics
  • Molecular Biology
  • Biochemistry
  • Computational Mathematics

Cite this

Comparative Analysis of Protein-Protein Interactions in Cancer-Associated Genes. / Guda, Purnima; Chittur, Sridar V.; Guda, Chittibabu.

In: Genomics, Proteomics and Bioinformatics, Vol. 7, No. 1-2, 01.06.2009, p. 25-36.

Research output: Contribution to journalArticle

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