Combined pancreas--kidney transplantation in Nebraska.

R. J. Stratta, R. J. Taylor, B. H. Zorn, C. Ozaki, Jennifer Lynn Larsen, Alan Norman Langnas, R. P. Wood, W. C. Duckworth, T. O. Wahl, T. F. Gallagher

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In the last 2 years, we have performed combined pancreas-kidney transplantation in 38 Type I diabetics with nephropathy. The mean age of the recipient group was 35 years (range 24-51) with a mean duration of diabetes of 22 years (range 13-41). All patients received quadruple immunosuppression with OKT3 induction. All patients are normoglycemic and insulin independent with a mean glycosylated hemoglobin level of 5.2 +/- 1.1% and a mean serum creatinine of 1.9 +/- 0.5 mg/dl. Metabolic effects of pancreas transplantation included fasting hyperinsulinemia and hyperglucagonemia with exaggerated insulin and glucagon responses to glucose and arginine, respectively, that improved slightly with time. Patient and kidney graft survival are 100% and pancreas graft survival is 94.7% after a mean follow-up interval of 15 months. Conclusion: Combined pancreas-kidney transplantation is the treatment of choice for selected Type I diabetics with nephropathy and results in euglycemia despite immunosuppression.

Original languageEnglish (US)
Pages (from-to)385-391
Number of pages7
JournalThe Nebraska medical journal
Volume76
Issue number12
StatePublished - Dec 1991

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Pancreas Transplantation
Kidney Transplantation
Diabetic Nephropathies
Graft Survival
Immunosuppression
Insulin
Muromonab-CD3
Glycosylated Hemoglobin A
Hyperinsulinism
Glucagon
Arginine
Pancreas
Fasting
Creatinine
Age Groups
Kidney
Glucose
Serum
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Stratta, R. J., Taylor, R. J., Zorn, B. H., Ozaki, C., Larsen, J. L., Langnas, A. N., ... Gallagher, T. F. (1991). Combined pancreas--kidney transplantation in Nebraska. The Nebraska medical journal, 76(12), 385-391.

Combined pancreas--kidney transplantation in Nebraska. / Stratta, R. J.; Taylor, R. J.; Zorn, B. H.; Ozaki, C.; Larsen, Jennifer Lynn; Langnas, Alan Norman; Wood, R. P.; Duckworth, W. C.; Wahl, T. O.; Gallagher, T. F.

In: The Nebraska medical journal, Vol. 76, No. 12, 12.1991, p. 385-391.

Research output: Contribution to journalArticle

Stratta, RJ, Taylor, RJ, Zorn, BH, Ozaki, C, Larsen, JL, Langnas, AN, Wood, RP, Duckworth, WC, Wahl, TO & Gallagher, TF 1991, 'Combined pancreas--kidney transplantation in Nebraska.', The Nebraska medical journal, vol. 76, no. 12, pp. 385-391.
Stratta RJ, Taylor RJ, Zorn BH, Ozaki C, Larsen JL, Langnas AN et al. Combined pancreas--kidney transplantation in Nebraska. The Nebraska medical journal. 1991 Dec;76(12):385-391.
Stratta, R. J. ; Taylor, R. J. ; Zorn, B. H. ; Ozaki, C. ; Larsen, Jennifer Lynn ; Langnas, Alan Norman ; Wood, R. P. ; Duckworth, W. C. ; Wahl, T. O. ; Gallagher, T. F. / Combined pancreas--kidney transplantation in Nebraska. In: The Nebraska medical journal. 1991 ; Vol. 76, No. 12. pp. 385-391.
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AU - Langnas, Alan Norman

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