Combined lung and liver transplantation

The United States experience

Neal R. Barshes, Daniel J. DiBardino, E. Dean McKenzie, Timothy C. Lee, Stephen A. Stayer, George B. Mallory, Saul J. Karpen, Ruben Quiros, Beth A. Carter, Charles D. Fraser, John A. Goss

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Background. Combined transplantation of the lungs and liver is indicated for patients who would not be expected to survive transplantation of either organ alone. No single center has accumulated a significant experience, and as a result the expectations for this operation in the current era are unknown. Methods. Patients that have undergone combined lung-liver transplantation in the United States were enrolled through the United Network for Organ Sharing Organ Procurement and Transplantation Network database. In addition, the English-language literature was searched for additional cases of combined lung-liver transplantation. Results. Eleven patients have undergone combined lung and liver transplantation in the United States at different centers. The 1- and 5-year patient survival rates are of 79% and 63%, respectively, and no patient has required retransplantation. These patient survival rates are equivalent to similar a combined lung-liver case series from the United Kingdom (P=0.37, log-rank test) and isolated orthotopic liver transplantation in the United States (P=0.59, log-rank test), and are comparable to patient survival rates following isolated lung transplantation in the United States. Conclusions. Patient survival of combined lung-liver transplantation is comparable to that of isolated liver and isolated bilateral lung transplantation. This option should be considered for patients with end-stage lung disease and liver disease when transplantation of a single organ transplantation is precluded by severe disease in the other organ system.

Original languageEnglish (US)
Pages (from-to)1161-1167
Number of pages7
JournalTransplantation
Volume80
Issue number9
DOIs
StatePublished - Nov 1 2005

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Lung Transplantation
Liver Transplantation
Organ Transplantation
Survival Rate
Tissue and Organ Procurement
Liver
Lung Diseases
Liver Diseases
Language
Transplantation
Databases
Lung
Survival

Keywords

  • Combined lung-liver transplant
  • Cystic fibrosis
  • Liver transplant
  • Lung transplant

ASJC Scopus subject areas

  • Transplantation

Cite this

Barshes, N. R., DiBardino, D. J., McKenzie, E. D., Lee, T. C., Stayer, S. A., Mallory, G. B., ... Goss, J. A. (2005). Combined lung and liver transplantation: The United States experience. Transplantation, 80(9), 1161-1167. https://doi.org/10.1097/01.tp.0000165717.23652.09

Combined lung and liver transplantation : The United States experience. / Barshes, Neal R.; DiBardino, Daniel J.; McKenzie, E. Dean; Lee, Timothy C.; Stayer, Stephen A.; Mallory, George B.; Karpen, Saul J.; Quiros, Ruben; Carter, Beth A.; Fraser, Charles D.; Goss, John A.

In: Transplantation, Vol. 80, No. 9, 01.11.2005, p. 1161-1167.

Research output: Contribution to journalArticle

Barshes, NR, DiBardino, DJ, McKenzie, ED, Lee, TC, Stayer, SA, Mallory, GB, Karpen, SJ, Quiros, R, Carter, BA, Fraser, CD & Goss, JA 2005, 'Combined lung and liver transplantation: The United States experience', Transplantation, vol. 80, no. 9, pp. 1161-1167. https://doi.org/10.1097/01.tp.0000165717.23652.09
Barshes NR, DiBardino DJ, McKenzie ED, Lee TC, Stayer SA, Mallory GB et al. Combined lung and liver transplantation: The United States experience. Transplantation. 2005 Nov 1;80(9):1161-1167. https://doi.org/10.1097/01.tp.0000165717.23652.09
Barshes, Neal R. ; DiBardino, Daniel J. ; McKenzie, E. Dean ; Lee, Timothy C. ; Stayer, Stephen A. ; Mallory, George B. ; Karpen, Saul J. ; Quiros, Ruben ; Carter, Beth A. ; Fraser, Charles D. ; Goss, John A. / Combined lung and liver transplantation : The United States experience. In: Transplantation. 2005 ; Vol. 80, No. 9. pp. 1161-1167.
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