Combined effects of cigarette smoking and alcohol consumption on perinatal outcome

Hein J. Odendaal, D. Wilhelm Steyn, Amy Elliott, Larry Burd

Research output: Contribution to journalReview article

54 Citations (Scopus)

Abstract

Background: An increase in various congenital abnormalities associated with cigarette smoking and the use of alcohol during pregnancy has been reported in many studies. These exposures also increase the risk of pregnancy complications such as abruptio placentae, unexplained stillbirth, preterm labor and intrauterine growth restriction. However, very few studies have addressed the combined effect of smoking and drinking on pregnancy outcomes. Methods: In this review, the adverse effects of smoking or drinking on pregnancy were obtained from publications in which both substances were addressed in the same study population. A special effort was made to find studies in which the combined effect of these substances was investigated. Results: Preterm labor occurred more frequently in women who drank and smoked during pregnancy. This increased odds ratio was more than the sum of the effects of either smoking or drinking, indicating that the use of both substances by the same woman has a synergistic effect that increases the risk of preterm labor. This synergistic effect was also found for low birth weight and growth restriction. Conclusions: As most of the women who drink during pregnancy also smoke cigarettes, attention should be given to the prevention or reduced use of both substances during pregnancy.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalGynecologic and Obstetric Investigation
Volume67
Issue number1
DOIs
StatePublished - Jan 1 2009

Fingerprint

Alcohol Drinking
Smoking
Premature Obstetric Labor
Pregnancy
Drinking
Abruptio Placentae
Stillbirth
Pregnancy Complications
Low Birth Weight Infant
Pregnancy Outcome
Growth
Smoke
Tobacco Products
Publications
Odds Ratio
Alcohols
Population

Keywords

  • Alcohol, prenatal
  • Pregnancy outcomes
  • Smoking, prenatal
  • Stillbirth

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Combined effects of cigarette smoking and alcohol consumption on perinatal outcome. / Odendaal, Hein J.; Steyn, D. Wilhelm; Elliott, Amy; Burd, Larry.

In: Gynecologic and Obstetric Investigation, Vol. 67, No. 1, 01.01.2009, p. 1-8.

Research output: Contribution to journalReview article

Odendaal, Hein J. ; Steyn, D. Wilhelm ; Elliott, Amy ; Burd, Larry. / Combined effects of cigarette smoking and alcohol consumption on perinatal outcome. In: Gynecologic and Obstetric Investigation. 2009 ; Vol. 67, No. 1. pp. 1-8.
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