Combinatorial catalysis employing a visible enzymatic beacon in real time: Synthetically versatile (Pseudo)halometalation/carbocyclizations

Jacob A. Friest, Sylvain Broussy, Woo Jin Chung, David B. Berkowitz

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

For the big screen: An alcohol oxidase/peroxidase-based screen for combinatorial catalysis produces a signal in the visible region and in real time. A targeted high-throughput screen uncovered a bromometalation/ carbocyclization route to bicyclic terpenoid cores and a thiocyano palladation/carbocyclization for the ready installation of vinyl thiocyanates.

Original languageEnglish (US)
Pages (from-to)8895-8899
Number of pages5
JournalAngewandte Chemie - International Edition
Volume50
Issue number38
DOIs
StatePublished - Sep 12 2011

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Keywords

  • carbocyclization
  • enzyme catalysis
  • heterocycles
  • stereoselective catalysis
  • synthetic methods

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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