Combinatorial catalysis employing a visible enzymatic beacon in real time: Synthetically versatile (Pseudo)halometalation/carbocyclizations

Jacob A. Friest, Sylvain Broussy, Woo Jin Chung, David B Berkowitz

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

For the big screen: An alcohol oxidase/peroxidase-based screen for combinatorial catalysis produces a signal in the visible region and in real time. A targeted high-throughput screen uncovered a bromometalation/ carbocyclization route to bicyclic terpenoid cores and a thiocyano palladation/carbocyclization for the ready installation of vinyl thiocyanates.

Original languageEnglish (US)
Pages (from-to)8895-8899
Number of pages5
JournalAngewandte Chemie - International Edition
Volume50
Issue number38
DOIs
StatePublished - Sep 12 2011

Fingerprint

alcohol oxidase
Thiocyanates
Terpenes
Catalysis
Peroxidase
Alcohols
Throughput
Oxidoreductases

Keywords

  • carbocyclization
  • enzyme catalysis
  • heterocycles
  • stereoselective catalysis
  • synthetic methods

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Cite this

Combinatorial catalysis employing a visible enzymatic beacon in real time : Synthetically versatile (Pseudo)halometalation/carbocyclizations. / Friest, Jacob A.; Broussy, Sylvain; Chung, Woo Jin; Berkowitz, David B.

In: Angewandte Chemie - International Edition, Vol. 50, No. 38, 12.09.2011, p. 8895-8899.

Research output: Contribution to journalArticle

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