Colostrum obtained from women vaccinated with pneumococcal vaccine during pregnancy inhibits epithelial adhesion of Streptococcus pneumoniae

Hedwig E. Deubzer, Stephen K. Obaro, Vanessa O. Newman, Richard A. Adegbola, Brian M. Greenwood, Don C. Henderson

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16 Scopus citations


Prevention of nasopharyngeal colonization may reduce the burden of pneumococcal infection during infancy. Colostrum obtained from Gambian mothers who had been vaccinated with either Pneumovax II or Mengivax A&C (n = 8 per group) during pregnancy was examined for inhibition of adherence of Streptococcus pneumoniae serotypes 6B and 14 to pharyngeal epithelial cells in vitro. Pneumococcal adherence was significantly reduced hi the presence of breast milk (P ≤ .0001 for S. pneumoniae serotype 14; P = .036 for serotype 6B), independent of the concentration of secretory IgA antibodies. Maternal vaccination with polyvalent pneumococcal polysaccharide vaccine boosts the capacity of colostrum to inhibit adherence of pneumococci to pharyngeal epithelial cells. In breast-feeding populations, maternal vaccination might prevent pneumococcal disease in young infants.

Original languageEnglish (US)
Pages (from-to)1758-1761
Number of pages4
JournalJournal of Infectious Diseases
Issue number10
StatePublished - Nov 15 2004


ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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