Colostrum obtained from women vaccinated with pneumococcal vaccine during pregnancy inhibits epithelial adhesion of Streptococcus pneumoniae

Hedwig E. Deubzer, Stephen K Obaro, Vanessa O. Newman, Richard A. Adegbola, Brian M. Greenwood, Don C. Henderson

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Prevention of nasopharyngeal colonization may reduce the burden of pneumococcal infection during infancy. Colostrum obtained from Gambian mothers who had been vaccinated with either Pneumovax II or Mengivax A&C (n = 8 per group) during pregnancy was examined for inhibition of adherence of Streptococcus pneumoniae serotypes 6B and 14 to pharyngeal epithelial cells in vitro. Pneumococcal adherence was significantly reduced hi the presence of breast milk (P ≤ .0001 for S. pneumoniae serotype 14; P = .036 for serotype 6B), independent of the concentration of secretory IgA antibodies. Maternal vaccination with polyvalent pneumococcal polysaccharide vaccine boosts the capacity of colostrum to inhibit adherence of pneumococci to pharyngeal epithelial cells. In breast-feeding populations, maternal vaccination might prevent pneumococcal disease in young infants.

Original languageEnglish (US)
Pages (from-to)1758-1761
Number of pages4
JournalJournal of Infectious Diseases
Volume190
Issue number10
DOIs
StatePublished - Nov 15 2004

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Pneumococcal Vaccines
Colostrum
Streptococcus pneumoniae
Mothers
Pregnancy
Vaccination
Epithelial Cells
Pneumococcal Infections
Secretory Immunoglobulin A
Human Milk
Breast Feeding
Antibodies
Population
Serogroup

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Colostrum obtained from women vaccinated with pneumococcal vaccine during pregnancy inhibits epithelial adhesion of Streptococcus pneumoniae. / Deubzer, Hedwig E.; Obaro, Stephen K; Newman, Vanessa O.; Adegbola, Richard A.; Greenwood, Brian M.; Henderson, Don C.

In: Journal of Infectious Diseases, Vol. 190, No. 10, 15.11.2004, p. 1758-1761.

Research output: Contribution to journalArticle

Deubzer, Hedwig E. ; Obaro, Stephen K ; Newman, Vanessa O. ; Adegbola, Richard A. ; Greenwood, Brian M. ; Henderson, Don C. / Colostrum obtained from women vaccinated with pneumococcal vaccine during pregnancy inhibits epithelial adhesion of Streptococcus pneumoniae. In: Journal of Infectious Diseases. 2004 ; Vol. 190, No. 10. pp. 1758-1761.
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