Colonic Bacteria

A Source of γ-Aminobutyric Acid in Blood (41169)

Daniel Francis Schafer, Jeffrey M. Fowler, E. Anthony Jones

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Blood contains more of the major inhibitory neurotransmitter, γ-aminobutyric acid (GABA), than does cerebrospinal fluid. However, the source and physiologic importance of this compound in the peripheral circulation are unknown. We have found that blood drawn from the portal vein of normal rabbits contains twice the concentration of GABA as that drawn simultaneously from the abdominal aorta. Also, human-derived colonic bacteria grown anaerobically secreted a large amount of GABA equivalents into culture media when measured by a radioreceptor technique. The production of inhibitory neuroactive substances, such as GABA, by colonic bacteria may play a role in the pathogenesis of certain disease states, for example, hepatic encephalopathy.

Original languageEnglish (US)
Pages (from-to)301-303
Number of pages3
JournalProceedings of the Society for Experimental Biology and Medicine
Volume167
Issue number3
DOIs
StatePublished - Jan 1 1981

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Aminobutyrates
gamma-Aminobutyric Acid
Bacteria
Blood
Cerebrospinal fluid
Hepatic Encephalopathy
Abdominal Aorta
Portal Vein
Neurotransmitter Agents
Culture Media
Cerebrospinal Fluid
Rabbits

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Colonic Bacteria : A Source of γ-Aminobutyric Acid in Blood (41169). / Schafer, Daniel Francis; Fowler, Jeffrey M.; Jones, E. Anthony.

In: Proceedings of the Society for Experimental Biology and Medicine, Vol. 167, No. 3, 01.01.1981, p. 301-303.

Research output: Contribution to journalArticle

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