Cognitive dysfunction in major depression and Alzheimer’s disease is associated with hippocampal–prefrontal cortex dysconnectivity

Dayalan Sampath, Monica Sathyanesan, Samuel Sathyanesan

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

Cognitive dysfunction is prevalent in psychiatric disorders. Deficits are observed in multiple domains, including working memory, executive function, attention, and information processing. Disability caused by cognitive dysfunction is frequently as debilitating as the prominent emotional disturbances. Interactions between the hippocampus and the prefrontal cortex are increasingly appreciated as an important link between cognition and emotion. Recent developments in optogenetics, imaging, and connectomics can enable the investigation of this circuit in a manner that is relevant to disease pathophysiology. The goal of this review is to shed light on the contributions of this circuit to cognitive dysfunction in neuropsychiatric disorders, focusing on Alzheimer’s disease and depression.

Original languageEnglish (US)
Pages (from-to)1509-1519
Number of pages11
JournalNeuropsychiatric Disease and Treatment
Volume13
DOIs
StatePublished - Jun 12 2017
Externally publishedYes

Fingerprint

Alzheimer Disease
Depression
Connectome
Optogenetics
Affective Symptoms
Executive Function
Prefrontal Cortex
Automatic Data Processing
Short-Term Memory
Cognition
Psychiatry
Hippocampus
Emotions
Cognitive Dysfunction

Keywords

  • Alzheimer’s disease
  • Cognition
  • Depression
  • Hippocampus
  • Prefrontal cortex

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Cognitive dysfunction in major depression and Alzheimer’s disease is associated with hippocampal–prefrontal cortex dysconnectivity. / Sampath, Dayalan; Sathyanesan, Monica; Sathyanesan, Samuel.

In: Neuropsychiatric Disease and Treatment, Vol. 13, 12.06.2017, p. 1509-1519.

Research output: Contribution to journalReview article

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