Cochlear microphonic and summating potential responses from click-evoked auditory brain stem responses in high-risk and normal infants

Lisa L. Hunter, Chelsea M. Blankenship, Rebekah G. Gunter, Douglas H. Keefe, M. Patrick Feeney, David K. Brownk, Kelly Baroch

Research output: Contribution to journalArticle

Abstract

Background: Examination of cochlear and neural potentials is necessary to assess sensory and neural status in infants, especially those cared for in neonatal intensive care units (NICU) who have high rates of hyperbilirubinemia and thus are at risk for auditory neuropathy (AN). Purpose: The purpose of this study was to determine whether recording parameters commonly used in click-evoked auditory brain stem response (ABR) are useful for recording cochlear microphonic (CM) and Wave I in infants at risk for AN. Specifically, we analyzed CM, summating potential (SP), and Waves I, III, and V. The overall aim was to compare latencies and amplitudes of evoked responses in infants cared for in NICUs with infants in a well-baby nursery (WBN), both of which passed newborn hearing screening. Research Design: This is a prospective study in which infants who passed ABR newborn hearing screening were grouped based on their birth history (WBN and NICU). All infants had normal hearing status when tested with diagnostic ABR at about one month of age, corrected for prematurity. Study Sample: Thirty infants (53 ears) from the WBN [mean corrected age at test 5 5.0 weeks (wks.)] and thirty-two infants (59 ears) from the NICU (mean corrected age at test 5 5.7 wks.) with normal hearing were included in this study. In addition, two infants were included as comparative case studies, one that was diagnosed with AN and another case that was diagnosed with bilateral sensorineural hearing loss (SNHL). Data Collection and Analysis: Diagnostic ABR, including click and tone-burst air- and bone-conduction stimuli were recorded. Peak Waves I, III, and V; SP; and CM latency and amplitude (peak to trough) were measured to determine if there were differences in ABR and electrocochleography (ECochG) variables between WBN and NICU infants. Results: No significant group differences were found between WBN and NICU groups for ABR waveforms, CM, or SP, including amplitude and latency values. The majority (75%) of the NICU group had hyperbilirubinemia, but overall, they did not show evidence of effects in their ECochG or ABR responses when tested at about one-month corrected age. These data may serve as a normative sample for NICU and well infant ECochG and ABR latencies at one-month corrected age. Two infant case studies, one diagnosed with AN and another with SNHL demonstrated the complexity of using ECochG and otoacoustic emissions to assess the risk of AN in individual cases.

Original languageEnglish (US)
Pages (from-to)427-442
Number of pages16
JournalJournal of the American Academy of Audiology
Volume29
Issue number5
DOIs
StatePublished - May 1 2018

Fingerprint

Cochlear Microphonic Potentials
Brain Stem Auditory Evoked Potentials
Neonatal Intensive Care Units
Evoked Response Audiometry
Nurseries
Hearing
Cochlea
Hyperbilirubinemia
Sensorineural Hearing Loss
Ear
Newborn Infant
Bilateral Hearing Loss
Bone Conduction
Reproductive History

Keywords

  • Auditory-evoked potentials
  • Diagnostic techniques
  • Otoacoustic emissions
  • Pediatric audiology

ASJC Scopus subject areas

  • Speech and Hearing

Cite this

Cochlear microphonic and summating potential responses from click-evoked auditory brain stem responses in high-risk and normal infants. / Hunter, Lisa L.; Blankenship, Chelsea M.; Gunter, Rebekah G.; Keefe, Douglas H.; Patrick Feeney, M.; Brownk, David K.; Baroch, Kelly.

In: Journal of the American Academy of Audiology, Vol. 29, No. 5, 01.05.2018, p. 427-442.

Research output: Contribution to journalArticle

Hunter, Lisa L. ; Blankenship, Chelsea M. ; Gunter, Rebekah G. ; Keefe, Douglas H. ; Patrick Feeney, M. ; Brownk, David K. ; Baroch, Kelly. / Cochlear microphonic and summating potential responses from click-evoked auditory brain stem responses in high-risk and normal infants. In: Journal of the American Academy of Audiology. 2018 ; Vol. 29, No. 5. pp. 427-442.
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AU - Patrick Feeney, M.

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