Coccolithoviruses: A review of cross‐kingdom genomic thievery and metabolic thuggery

Jozef I. Nissimov, António Pagarete, Fangrui Ma, Sean Cody, David D. Dunigan, Susan A. Kimmance, Michael J. Allen

Research output: Contribution to journalReview article

8 Citations (Scopus)

Abstract

Coccolithoviruses (Phycodnaviridae) infect and lyse the most ubiquitous and successful coccolithophorid in modern oceans, Emiliania huxleyi. So far, the genomes of 13 of these giant lytic viruses (i.e., Emiliania huxleyi viruses—EhVs) have been sequenced, assembled, and annotated. Here, we performed an in‐depth comparison of their genomes to try and contextualize the ecological and evolutionary traits of these viruses. The genomes of these EhVs have from 444 to 548 coding sequences (CDSs). Presence/absence analysis of CDSs identified putative genes with particular ecological significance, namely sialidase, phosphate permease, and sphingolipid biosynthesis. The viruses clustered into distinct clades, based on their DNA polymerase gene as well as full genome comparisons. We discuss the use of such clustering and suggest that a gene‐by‐gene investigation approach may be more useful when the goal is to reveal differences related to functionally important genes. A multi domain “Best BLAST hit” analysis revealed that 84% of the EhV genes have closer similarities to the domain Eukarya. However, 16% of the EhV CDSs were very similar to bacterial genes, contributing to the idea that a significant portion of the gene flow in the planktonic world inter‐crosses the domains of life.

Original languageEnglish (US)
Article number52
JournalViruses
Volume9
Issue number3
DOIs
StatePublished - Mar 18 2017

Fingerprint

Haptophyta
Genome
Genes
Phycodnaviridae
Viruses
Bacterial Genes
Sphingolipids
Gene Flow
Neuraminidase
DNA-Directed DNA Polymerase
Eukaryota
Oceans and Seas
Sequence Analysis
Cluster Analysis

Keywords

  • Coccolithovirus
  • Domains of life
  • E. huxleyi
  • Genome comparison
  • Horizontal gene transfer

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

Cite this

Nissimov, J. I., Pagarete, A., Ma, F., Cody, S., Dunigan, D. D., Kimmance, S. A., & Allen, M. J. (2017). Coccolithoviruses: A review of cross‐kingdom genomic thievery and metabolic thuggery. Viruses, 9(3), [52]. https://doi.org/10.3390/v9030052

Coccolithoviruses : A review of cross‐kingdom genomic thievery and metabolic thuggery. / Nissimov, Jozef I.; Pagarete, António; Ma, Fangrui; Cody, Sean; Dunigan, David D.; Kimmance, Susan A.; Allen, Michael J.

In: Viruses, Vol. 9, No. 3, 52, 18.03.2017.

Research output: Contribution to journalReview article

Nissimov, JI, Pagarete, A, Ma, F, Cody, S, Dunigan, DD, Kimmance, SA & Allen, MJ 2017, 'Coccolithoviruses: A review of cross‐kingdom genomic thievery and metabolic thuggery', Viruses, vol. 9, no. 3, 52. https://doi.org/10.3390/v9030052
Nissimov, Jozef I. ; Pagarete, António ; Ma, Fangrui ; Cody, Sean ; Dunigan, David D. ; Kimmance, Susan A. ; Allen, Michael J. / Coccolithoviruses : A review of cross‐kingdom genomic thievery and metabolic thuggery. In: Viruses. 2017 ; Vol. 9, No. 3.
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