Cocaine and HIV-1 interplay

Molecular mechanisms of action and addiction

Shilpa J Buch, Honghong Yao, Minglei Guo, Tomohisa Mori, Tsung Ping Su, John Wang

Research output: Contribution to journalReview article

32 Citations (Scopus)

Abstract

Human immunodeficiency virus (HIV) infection is now being driven by drug-abusing populations. Epidemiological studies on drug abusers with AIDS link abuse of cocaine, even more than other drugs, to increased incidence of HIV seroprevalence and progression to AIDS. Both cell culture and animal studies demonstrate that cocaine can both potentiate HIV replication and can potentiate HIV proteins to cause enhanced glial cell activation, neurotoxicity, and breakdown of the blood-brain barrier. Based on the ability of both HIV proteins and cocaine to modulate NMDA receptor on neurons, NMDA receptors have been suggested as a common link underlying the crosstalk between drug addiction and HIV infection. While the role of dopamine system as a major target of cocaine cannot be overlooked, recent studies on the role of sigma receptors in mediating the effects of cocaine in both cell and organ systems warrants a deeper understanding of their functional role in the field. In this review, recent findings on the interplay of HIV infection and cocaine abuse and their possible implications in mode of action and/or addiction will be discussed.

Original languageEnglish (US)
Pages (from-to)503-515
Number of pages13
JournalJournal of Neuroimmune Pharmacology
Volume6
Issue number4
DOIs
StatePublished - Dec 1 2011

Fingerprint

Cocaine
HIV-1
HIV
Virus Diseases
Human Immunodeficiency Virus Proteins
Cocaine-Related Disorders
N-Methyl-D-Aspartate Receptors
Acquired Immunodeficiency Syndrome
sigma Receptors
Aptitude
Seroepidemiologic Studies
Virus Replication
Drug Users
Blood-Brain Barrier
Neuroglia
Pharmaceutical Preparations
Substance-Related Disorders
Epidemiologic Studies
Dopamine
Cell Culture Techniques

Keywords

  • CNS
  • Cocaine
  • HIV

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Immunology and Allergy
  • Immunology
  • Pharmacology

Cite this

Cocaine and HIV-1 interplay : Molecular mechanisms of action and addiction. / Buch, Shilpa J; Yao, Honghong; Guo, Minglei; Mori, Tomohisa; Su, Tsung Ping; Wang, John.

In: Journal of Neuroimmune Pharmacology, Vol. 6, No. 4, 01.12.2011, p. 503-515.

Research output: Contribution to journalReview article

Buch, Shilpa J ; Yao, Honghong ; Guo, Minglei ; Mori, Tomohisa ; Su, Tsung Ping ; Wang, John. / Cocaine and HIV-1 interplay : Molecular mechanisms of action and addiction. In: Journal of Neuroimmune Pharmacology. 2011 ; Vol. 6, No. 4. pp. 503-515.
@article{4cda7f20e116434b8b61893fe54ada74,
title = "Cocaine and HIV-1 interplay: Molecular mechanisms of action and addiction",
abstract = "Human immunodeficiency virus (HIV) infection is now being driven by drug-abusing populations. Epidemiological studies on drug abusers with AIDS link abuse of cocaine, even more than other drugs, to increased incidence of HIV seroprevalence and progression to AIDS. Both cell culture and animal studies demonstrate that cocaine can both potentiate HIV replication and can potentiate HIV proteins to cause enhanced glial cell activation, neurotoxicity, and breakdown of the blood-brain barrier. Based on the ability of both HIV proteins and cocaine to modulate NMDA receptor on neurons, NMDA receptors have been suggested as a common link underlying the crosstalk between drug addiction and HIV infection. While the role of dopamine system as a major target of cocaine cannot be overlooked, recent studies on the role of sigma receptors in mediating the effects of cocaine in both cell and organ systems warrants a deeper understanding of their functional role in the field. In this review, recent findings on the interplay of HIV infection and cocaine abuse and their possible implications in mode of action and/or addiction will be discussed.",
keywords = "CNS, Cocaine, HIV",
author = "Buch, {Shilpa J} and Honghong Yao and Minglei Guo and Tomohisa Mori and Su, {Tsung Ping} and John Wang",
year = "2011",
month = "12",
day = "1",
doi = "10.1007/s11481-011-9297-0",
language = "English (US)",
volume = "6",
pages = "503--515",
journal = "Journal of NeuroImmune Pharmacology",
issn = "1557-1890",
publisher = "Springer New York",
number = "4",

}

TY - JOUR

T1 - Cocaine and HIV-1 interplay

T2 - Molecular mechanisms of action and addiction

AU - Buch, Shilpa J

AU - Yao, Honghong

AU - Guo, Minglei

AU - Mori, Tomohisa

AU - Su, Tsung Ping

AU - Wang, John

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Human immunodeficiency virus (HIV) infection is now being driven by drug-abusing populations. Epidemiological studies on drug abusers with AIDS link abuse of cocaine, even more than other drugs, to increased incidence of HIV seroprevalence and progression to AIDS. Both cell culture and animal studies demonstrate that cocaine can both potentiate HIV replication and can potentiate HIV proteins to cause enhanced glial cell activation, neurotoxicity, and breakdown of the blood-brain barrier. Based on the ability of both HIV proteins and cocaine to modulate NMDA receptor on neurons, NMDA receptors have been suggested as a common link underlying the crosstalk between drug addiction and HIV infection. While the role of dopamine system as a major target of cocaine cannot be overlooked, recent studies on the role of sigma receptors in mediating the effects of cocaine in both cell and organ systems warrants a deeper understanding of their functional role in the field. In this review, recent findings on the interplay of HIV infection and cocaine abuse and their possible implications in mode of action and/or addiction will be discussed.

AB - Human immunodeficiency virus (HIV) infection is now being driven by drug-abusing populations. Epidemiological studies on drug abusers with AIDS link abuse of cocaine, even more than other drugs, to increased incidence of HIV seroprevalence and progression to AIDS. Both cell culture and animal studies demonstrate that cocaine can both potentiate HIV replication and can potentiate HIV proteins to cause enhanced glial cell activation, neurotoxicity, and breakdown of the blood-brain barrier. Based on the ability of both HIV proteins and cocaine to modulate NMDA receptor on neurons, NMDA receptors have been suggested as a common link underlying the crosstalk between drug addiction and HIV infection. While the role of dopamine system as a major target of cocaine cannot be overlooked, recent studies on the role of sigma receptors in mediating the effects of cocaine in both cell and organ systems warrants a deeper understanding of their functional role in the field. In this review, recent findings on the interplay of HIV infection and cocaine abuse and their possible implications in mode of action and/or addiction will be discussed.

KW - CNS

KW - Cocaine

KW - HIV

UR - http://www.scopus.com/inward/record.url?scp=81355149770&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=81355149770&partnerID=8YFLogxK

U2 - 10.1007/s11481-011-9297-0

DO - 10.1007/s11481-011-9297-0

M3 - Review article

VL - 6

SP - 503

EP - 515

JO - Journal of NeuroImmune Pharmacology

JF - Journal of NeuroImmune Pharmacology

SN - 1557-1890

IS - 4

ER -