Cocaine and HIV-1 interplay in CNS: Cellular and molecular mechanisms

Shilpa Buch, Honghong Yao, Minglei Guo, Tomohisa Mori, Blaise Mathias-Costa, Vijeta Singh, Pankaj Seth, John Wang, Tsung Ping Su

Research output: Contribution to journalReview article

44 Scopus citations

Abstract

Although antiretrovirals are the mainstay of therapy against HIV infection, neurological complications associated with the virus continue to hamper quality of life of the infected individuals. Drugs of abuse in the infected individuals further fuel the epidemic. Epidemiological studies have demonstrated that abuse of cocaine resulted in acceleration of HIV infection and the progression of Neuro AIDS. Cocaine has not only been shown to play a crucial role in promoting virus replication, but also has diverse but often deleterious effects on various cell types of the CNS. In the neuronal system, cocaine exposure results in neuronal toxicity and also potentiates gp120-induced neurotoxicity. In the astroglia and micro glia, cocaine exposure leads to up-regulation of pro-inflammatory mediators such as cytokines and chemokines. These in turn, can lead to neuro inflammation and transmission of toxic responses to the neurons. Additionally, cocaine exposure can also lead to leakiness of the blood-brain barrier that manifests as enhanced transmigraiton of leukocytes/monocytes into the CNS. Both in vitro and in vivo studies have provided valuable tools in exploring the role of cocaine in mediating HIV-associated neuropathogenesis. This review summarizes previous studies on the mechanism(s) underlying the interplay of cocaine and HIV as it relates to the CNS.

Original languageEnglish (US)
Pages (from-to)425-428
Number of pages4
JournalCurrent HIV research
Volume10
Issue number5
DOIs
StatePublished - Sep 21 2012

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Keywords

  • AIDS
  • Cocaine
  • Glial cell
  • HIV
  • HIV-1-associated neurocognitive disorders
  • Neuron

ASJC Scopus subject areas

  • Infectious Diseases
  • Virology

Cite this

Buch, S., Yao, H., Guo, M., Mori, T., Mathias-Costa, B., Singh, V., Seth, P., Wang, J., & Su, T. P. (2012). Cocaine and HIV-1 interplay in CNS: Cellular and molecular mechanisms. Current HIV research, 10(5), 425-428. https://doi.org/10.2174/157016212802138823