Clostridium difficile-associated infection: A disease of varying severity

Randeep S. Jawa, David W Mercer

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Clostridium difficile-associated infection (CDI) can have varying severity from asymptomatic carriage to fulminant colitis. Its incidence and virulence in North America are increasing. The increase in virulence is associated with emergence of the highly toxigenic North American pulsed field gel electrophoresis-1 strain. The major risk factor for CDI is exposure to antibiotics. Another major risk factor is hospitalization. The spectrum of CDI ranges from asymptomatic carriers to fulminant disease. Although asymptomatic carriers require no treatment, fulminant disease carries a substantial mortality regardless of management strategy.

Original languageEnglish (US)
Pages (from-to)836-842
Number of pages7
JournalAmerican journal of surgery
Volume204
Issue number6
DOIs
StatePublished - Dec 1 2012

Fingerprint

Clostridium difficile
Virulence
Infection
Asymptomatic Infections
Pulsed Field Gel Electrophoresis
Colitis
North America
Hospitalization
Anti-Bacterial Agents
Mortality
Incidence
Therapeutics

Keywords

  • Antibiotics
  • Clostridium difficile
  • Colitis
  • Diarrhea
  • Thomas Orr lecture

ASJC Scopus subject areas

  • Surgery

Cite this

Clostridium difficile-associated infection : A disease of varying severity. / Jawa, Randeep S.; Mercer, David W.

In: American journal of surgery, Vol. 204, No. 6, 01.12.2012, p. 836-842.

Research output: Contribution to journalArticle

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