Clinicopathologic factors associated with lymph node retrieval in resectable colon cancer

A veterans' affairs central cancer registry (VACCR) database analysis

Wilson I. Gonsalves, Swapna Kanuri, Tsewang Tashi, Ibrahim Aldoss, Ashwin Sama, Islam Al-Howaidi, Ashwin Ganta, Mudappa Kalaiah, Ramya Thota, Jairam Krishnamurthy, Xiang Fang, Peter Townley, Apar Kishor P Ganti, Shanmuga Subbiah, Peter T. Silberstein

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: A long-term determinant of survival in resectable colon cancer is the involvement of regional lymph nodes. We evaluated the clinicopathologic factors associated with lymph node retrieval. Methods: We conducted a retrospective analysis of patients with resected stage I-III colon cancer in the Veteran's Affairs Central Cancer Registry between 1995 and 2008. One-way ANOVA compared the differences between various groups. Multivariate logistic regression analysis was performed to determine the factors associated with the harvest of 12 or more lymph nodes for pathologic examination. Results: There were 19,240 patients with resectable colon cancer included in our analysis. Mean number of lymph nodes retrieved increased with later year of diagnosis, higher overall stage, higher T descriptor, age <65 years, poorer differentiation and right-sided tumors (P<0.01 for all covariates). These aforementioned factors are also associated with an increased probability of retrieving 12 or more lymph nodes after surgical resection (P<0.01 for all covariates). Conclusions: Later year of diagnosis, younger patients, right-sided tumors, poorer differentiation, higher T descriptor and overall stage are associated with increased number of lymph nodes retrieved. These may indicate the presence of an immunological response of tumor versus host affecting lymph node retrieval.

Original languageEnglish (US)
Pages (from-to)667-671
Number of pages5
JournalJournal of Surgical Oncology
Volume104
Issue number6
DOIs
StatePublished - Nov 1 2011

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Veterans
Colonic Neoplasms
Registries
Lymph Nodes
Databases
Neoplasms
Delayed Diagnosis
Patient Rights
Analysis of Variance
Logistic Models
Regression Analysis
Survival

Keywords

  • VACCR
  • clinicopathologic features
  • colon cancer
  • lymph node yield

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Clinicopathologic factors associated with lymph node retrieval in resectable colon cancer : A veterans' affairs central cancer registry (VACCR) database analysis. / Gonsalves, Wilson I.; Kanuri, Swapna; Tashi, Tsewang; Aldoss, Ibrahim; Sama, Ashwin; Al-Howaidi, Islam; Ganta, Ashwin; Kalaiah, Mudappa; Thota, Ramya; Krishnamurthy, Jairam; Fang, Xiang; Townley, Peter; Ganti, Apar Kishor P; Subbiah, Shanmuga; Silberstein, Peter T.

In: Journal of Surgical Oncology, Vol. 104, No. 6, 01.11.2011, p. 667-671.

Research output: Contribution to journalArticle

Gonsalves, WI, Kanuri, S, Tashi, T, Aldoss, I, Sama, A, Al-Howaidi, I, Ganta, A, Kalaiah, M, Thota, R, Krishnamurthy, J, Fang, X, Townley, P, Ganti, AKP, Subbiah, S & Silberstein, PT 2011, 'Clinicopathologic factors associated with lymph node retrieval in resectable colon cancer: A veterans' affairs central cancer registry (VACCR) database analysis', Journal of Surgical Oncology, vol. 104, no. 6, pp. 667-671. https://doi.org/10.1002/jso.21886
Gonsalves, Wilson I. ; Kanuri, Swapna ; Tashi, Tsewang ; Aldoss, Ibrahim ; Sama, Ashwin ; Al-Howaidi, Islam ; Ganta, Ashwin ; Kalaiah, Mudappa ; Thota, Ramya ; Krishnamurthy, Jairam ; Fang, Xiang ; Townley, Peter ; Ganti, Apar Kishor P ; Subbiah, Shanmuga ; Silberstein, Peter T. / Clinicopathologic factors associated with lymph node retrieval in resectable colon cancer : A veterans' affairs central cancer registry (VACCR) database analysis. In: Journal of Surgical Oncology. 2011 ; Vol. 104, No. 6. pp. 667-671.
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