Clinical Significance of Benign Glands at Surgical Margins in Robotic Radical Prostatectomy Specimens

Shane K. Kohl, Kethandapatti C. Balaji, Lynette M Smith, Nicholas P. Wilson, Sonny L. Johansson, Samuel P. Sterrett, Neil A. Abrahams

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objectives: Completion of robotic radical prostatectomy compared with conventional open retropubic radical prostatectomy can result in different alterations in the prostatectomy specimens. One difference appears to be an increased incidence of benign glands at the margins, which has been associated with an increase in postoperative prostatic-specific antigen (PSA) levels. We compared the frequency and clinical significance of benign prostate glands at the surgical margins in radical prostatectomy specimens obtained by robotic versus open retropubic prostatectomy. Methods: We reviewed 38 consecutive prostatectomy specimens from patients with biopsy-proven prostate cancer. Of these 38 specimens, 25 (65%) were obtained by robotic resection and 13 (35%) by open retropubic prostatectomy. Each case was analyzed for Gleason score, pathologic stage, including margin status, and the presence or absence of benign glands at the surgical margin. The study endpoint was the postoperative serum PSA level. Results: A significantly greater incidence (P = 0.035) of benign glands at the surgical margins was found within the robotic group compared with the open retropubic prostatectomy group (54% versus 15%). With a median follow-up of 12.5 months for the robotic group and 24.5 months for the robotic prostatectomy group, only 2 patients, who also had had positive surgical margins, had a continued and persistent increase in the postoperative PSA level after an initial nadir. Conclusions: The early clinical follow-up data of our study have suggested that patients undergoing robotic radical prostatectomy with negative surgical margins achieve a PSA nadir of less than 0.1 ng/mL, irrespective of the presence or absence of benign prostatic tissue at the surgical margins.

Original languageEnglish (US)
Pages (from-to)1112-1116
Number of pages5
JournalUrology
Volume69
Issue number6
DOIs
StatePublished - Jun 1 2007

Fingerprint

Robotics
Prostatectomy
Antigens
Margins of Excision
Neoplasm Grading
Incidence
Prostate
Prostatic Neoplasms
Biopsy

ASJC Scopus subject areas

  • Urology

Cite this

Kohl, S. K., Balaji, K. C., Smith, L. M., Wilson, N. P., Johansson, S. L., Sterrett, S. P., & Abrahams, N. A. (2007). Clinical Significance of Benign Glands at Surgical Margins in Robotic Radical Prostatectomy Specimens. Urology, 69(6), 1112-1116. https://doi.org/10.1016/j.urology.2007.02.048

Clinical Significance of Benign Glands at Surgical Margins in Robotic Radical Prostatectomy Specimens. / Kohl, Shane K.; Balaji, Kethandapatti C.; Smith, Lynette M; Wilson, Nicholas P.; Johansson, Sonny L.; Sterrett, Samuel P.; Abrahams, Neil A.

In: Urology, Vol. 69, No. 6, 01.06.2007, p. 1112-1116.

Research output: Contribution to journalArticle

Kohl, SK, Balaji, KC, Smith, LM, Wilson, NP, Johansson, SL, Sterrett, SP & Abrahams, NA 2007, 'Clinical Significance of Benign Glands at Surgical Margins in Robotic Radical Prostatectomy Specimens', Urology, vol. 69, no. 6, pp. 1112-1116. https://doi.org/10.1016/j.urology.2007.02.048
Kohl, Shane K. ; Balaji, Kethandapatti C. ; Smith, Lynette M ; Wilson, Nicholas P. ; Johansson, Sonny L. ; Sterrett, Samuel P. ; Abrahams, Neil A. / Clinical Significance of Benign Glands at Surgical Margins in Robotic Radical Prostatectomy Specimens. In: Urology. 2007 ; Vol. 69, No. 6. pp. 1112-1116.
@article{a96993ff848b4e7d8faa41baf8323272,
title = "Clinical Significance of Benign Glands at Surgical Margins in Robotic Radical Prostatectomy Specimens",
abstract = "Objectives: Completion of robotic radical prostatectomy compared with conventional open retropubic radical prostatectomy can result in different alterations in the prostatectomy specimens. One difference appears to be an increased incidence of benign glands at the margins, which has been associated with an increase in postoperative prostatic-specific antigen (PSA) levels. We compared the frequency and clinical significance of benign prostate glands at the surgical margins in radical prostatectomy specimens obtained by robotic versus open retropubic prostatectomy. Methods: We reviewed 38 consecutive prostatectomy specimens from patients with biopsy-proven prostate cancer. Of these 38 specimens, 25 (65{\%}) were obtained by robotic resection and 13 (35{\%}) by open retropubic prostatectomy. Each case was analyzed for Gleason score, pathologic stage, including margin status, and the presence or absence of benign glands at the surgical margin. The study endpoint was the postoperative serum PSA level. Results: A significantly greater incidence (P = 0.035) of benign glands at the surgical margins was found within the robotic group compared with the open retropubic prostatectomy group (54{\%} versus 15{\%}). With a median follow-up of 12.5 months for the robotic group and 24.5 months for the robotic prostatectomy group, only 2 patients, who also had had positive surgical margins, had a continued and persistent increase in the postoperative PSA level after an initial nadir. Conclusions: The early clinical follow-up data of our study have suggested that patients undergoing robotic radical prostatectomy with negative surgical margins achieve a PSA nadir of less than 0.1 ng/mL, irrespective of the presence or absence of benign prostatic tissue at the surgical margins.",
author = "Kohl, {Shane K.} and Balaji, {Kethandapatti C.} and Smith, {Lynette M} and Wilson, {Nicholas P.} and Johansson, {Sonny L.} and Sterrett, {Samuel P.} and Abrahams, {Neil A.}",
year = "2007",
month = "6",
day = "1",
doi = "10.1016/j.urology.2007.02.048",
language = "English (US)",
volume = "69",
pages = "1112--1116",
journal = "Urology",
issn = "0090-4295",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - Clinical Significance of Benign Glands at Surgical Margins in Robotic Radical Prostatectomy Specimens

AU - Kohl, Shane K.

AU - Balaji, Kethandapatti C.

AU - Smith, Lynette M

AU - Wilson, Nicholas P.

AU - Johansson, Sonny L.

AU - Sterrett, Samuel P.

AU - Abrahams, Neil A.

PY - 2007/6/1

Y1 - 2007/6/1

N2 - Objectives: Completion of robotic radical prostatectomy compared with conventional open retropubic radical prostatectomy can result in different alterations in the prostatectomy specimens. One difference appears to be an increased incidence of benign glands at the margins, which has been associated with an increase in postoperative prostatic-specific antigen (PSA) levels. We compared the frequency and clinical significance of benign prostate glands at the surgical margins in radical prostatectomy specimens obtained by robotic versus open retropubic prostatectomy. Methods: We reviewed 38 consecutive prostatectomy specimens from patients with biopsy-proven prostate cancer. Of these 38 specimens, 25 (65%) were obtained by robotic resection and 13 (35%) by open retropubic prostatectomy. Each case was analyzed for Gleason score, pathologic stage, including margin status, and the presence or absence of benign glands at the surgical margin. The study endpoint was the postoperative serum PSA level. Results: A significantly greater incidence (P = 0.035) of benign glands at the surgical margins was found within the robotic group compared with the open retropubic prostatectomy group (54% versus 15%). With a median follow-up of 12.5 months for the robotic group and 24.5 months for the robotic prostatectomy group, only 2 patients, who also had had positive surgical margins, had a continued and persistent increase in the postoperative PSA level after an initial nadir. Conclusions: The early clinical follow-up data of our study have suggested that patients undergoing robotic radical prostatectomy with negative surgical margins achieve a PSA nadir of less than 0.1 ng/mL, irrespective of the presence or absence of benign prostatic tissue at the surgical margins.

AB - Objectives: Completion of robotic radical prostatectomy compared with conventional open retropubic radical prostatectomy can result in different alterations in the prostatectomy specimens. One difference appears to be an increased incidence of benign glands at the margins, which has been associated with an increase in postoperative prostatic-specific antigen (PSA) levels. We compared the frequency and clinical significance of benign prostate glands at the surgical margins in radical prostatectomy specimens obtained by robotic versus open retropubic prostatectomy. Methods: We reviewed 38 consecutive prostatectomy specimens from patients with biopsy-proven prostate cancer. Of these 38 specimens, 25 (65%) were obtained by robotic resection and 13 (35%) by open retropubic prostatectomy. Each case was analyzed for Gleason score, pathologic stage, including margin status, and the presence or absence of benign glands at the surgical margin. The study endpoint was the postoperative serum PSA level. Results: A significantly greater incidence (P = 0.035) of benign glands at the surgical margins was found within the robotic group compared with the open retropubic prostatectomy group (54% versus 15%). With a median follow-up of 12.5 months for the robotic group and 24.5 months for the robotic prostatectomy group, only 2 patients, who also had had positive surgical margins, had a continued and persistent increase in the postoperative PSA level after an initial nadir. Conclusions: The early clinical follow-up data of our study have suggested that patients undergoing robotic radical prostatectomy with negative surgical margins achieve a PSA nadir of less than 0.1 ng/mL, irrespective of the presence or absence of benign prostatic tissue at the surgical margins.

UR - http://www.scopus.com/inward/record.url?scp=34250009784&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34250009784&partnerID=8YFLogxK

U2 - 10.1016/j.urology.2007.02.048

DO - 10.1016/j.urology.2007.02.048

M3 - Article

C2 - 17572197

AN - SCOPUS:34250009784

VL - 69

SP - 1112

EP - 1116

JO - Urology

JF - Urology

SN - 0090-4295

IS - 6

ER -