Clinical presentation and treatment of transfusion-associated babesiosis in premature infants

Kari A Simonsen, Joseph I. Harwell, Shabnam Lainwala

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We review here 7 cases of neonatal transfusion-associated babesiosis at a NICU in the northeast United States. Transfusion from 2 infected units of blood resulted in the 7 cases described. The clinical presentation was highly variable in this cohort; the extremely low birth weight neonates were the most severely affected. Antibiotic therapy was effective in neonates with mild and asymptomatic infection; however, double-volume exchange blood transfusion with prolonged multidrug treatment was required for the 2 most severe cases. The risk of Babesia microti infection is not eliminated through current blood-bank practices. Neonatologists in endemic areas should have a high index of suspicion for babesiosis in premature infants exposed to blood transfusions.

Original languageEnglish (US)
JournalPediatrics
Volume128
Issue number4
DOIs
StatePublished - Oct 1 2011

Fingerprint

Babesiosis
Premature Infants
Blood Transfusion
Babesia microti
Newborn Infant
Blood Banks
Asymptomatic Infections
Low Birth Weight Infant
Anti-Bacterial Agents
Therapeutics
Infection
Transfusion
Blood
Neonatologists

Keywords

  • Babesia
  • Babesiosis/ parasitology
  • Babesiosis/diagnosis
  • Babesiosis/transmission
  • Blood transfusion/adverse effects
  • Infant
  • Parasitemia/diagnosis
  • Parasitemia/transmission
  • Premature/diseases
  • Premature/parasitology

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Clinical presentation and treatment of transfusion-associated babesiosis in premature infants. / Simonsen, Kari A; Harwell, Joseph I.; Lainwala, Shabnam.

In: Pediatrics, Vol. 128, No. 4, 01.10.2011.

Research output: Contribution to journalArticle

@article{9f73ea2ca81c49c189824837b37ad1e6,
title = "Clinical presentation and treatment of transfusion-associated babesiosis in premature infants",
abstract = "We review here 7 cases of neonatal transfusion-associated babesiosis at a NICU in the northeast United States. Transfusion from 2 infected units of blood resulted in the 7 cases described. The clinical presentation was highly variable in this cohort; the extremely low birth weight neonates were the most severely affected. Antibiotic therapy was effective in neonates with mild and asymptomatic infection; however, double-volume exchange blood transfusion with prolonged multidrug treatment was required for the 2 most severe cases. The risk of Babesia microti infection is not eliminated through current blood-bank practices. Neonatologists in endemic areas should have a high index of suspicion for babesiosis in premature infants exposed to blood transfusions.",
keywords = "Babesia, Babesiosis/ parasitology, Babesiosis/diagnosis, Babesiosis/transmission, Blood transfusion/adverse effects, Infant, Parasitemia/diagnosis, Parasitemia/transmission, Premature/diseases, Premature/parasitology",
author = "Simonsen, {Kari A} and Harwell, {Joseph I.} and Shabnam Lainwala",
year = "2011",
month = "10",
day = "1",
doi = "10.1542/peds.2010-0502",
language = "English (US)",
volume = "128",
journal = "Pediatrics",
issn = "0031-4005",
publisher = "American Academy of Pediatrics",
number = "4",

}

TY - JOUR

T1 - Clinical presentation and treatment of transfusion-associated babesiosis in premature infants

AU - Simonsen, Kari A

AU - Harwell, Joseph I.

AU - Lainwala, Shabnam

PY - 2011/10/1

Y1 - 2011/10/1

N2 - We review here 7 cases of neonatal transfusion-associated babesiosis at a NICU in the northeast United States. Transfusion from 2 infected units of blood resulted in the 7 cases described. The clinical presentation was highly variable in this cohort; the extremely low birth weight neonates were the most severely affected. Antibiotic therapy was effective in neonates with mild and asymptomatic infection; however, double-volume exchange blood transfusion with prolonged multidrug treatment was required for the 2 most severe cases. The risk of Babesia microti infection is not eliminated through current blood-bank practices. Neonatologists in endemic areas should have a high index of suspicion for babesiosis in premature infants exposed to blood transfusions.

AB - We review here 7 cases of neonatal transfusion-associated babesiosis at a NICU in the northeast United States. Transfusion from 2 infected units of blood resulted in the 7 cases described. The clinical presentation was highly variable in this cohort; the extremely low birth weight neonates were the most severely affected. Antibiotic therapy was effective in neonates with mild and asymptomatic infection; however, double-volume exchange blood transfusion with prolonged multidrug treatment was required for the 2 most severe cases. The risk of Babesia microti infection is not eliminated through current blood-bank practices. Neonatologists in endemic areas should have a high index of suspicion for babesiosis in premature infants exposed to blood transfusions.

KW - Babesia

KW - Babesiosis/ parasitology

KW - Babesiosis/diagnosis

KW - Babesiosis/transmission

KW - Blood transfusion/adverse effects

KW - Infant

KW - Parasitemia/diagnosis

KW - Parasitemia/transmission

KW - Premature/diseases

KW - Premature/parasitology

UR - http://www.scopus.com/inward/record.url?scp=80053551787&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80053551787&partnerID=8YFLogxK

U2 - 10.1542/peds.2010-0502

DO - 10.1542/peds.2010-0502

M3 - Article

VL - 128

JO - Pediatrics

JF - Pediatrics

SN - 0031-4005

IS - 4

ER -