Clinical, histopathological and immunohistochemical findings in a case of megakaryoblastic leukemia in a dog

Hee Myung Park, Alan R Doster, Roksana E. Tashbaeva, Young Mee Lee, Young S. Lyoo, Sang Jin Lee, Hee Jung Kim, Jung Hyang Sur

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The clinical, hematological, and histopathologic features of megakaryoblastic leukemia (M7) were investigated in a 10-year-old female Shih-Tzu dog. Megakaryoblastic leukemia was diagnosed using antihuman platelet glycoprotein (GP IIIa) and anti-human von Willebrand factor (vWF) antibodies. The expression of CD antigen on megakaryoblasts was also assessed using a CD79a monoclonal antibody. Immunological markers allowed visualization of neoplastic megakaryocytes. Antibodies against platelet GP IIIa were demonstrated to be the most useful for the diagnosis of megakaryoblastic leukemia of paraffin-embedded canine tissues. Hematological and histological data coupled with immunohistochemical reactivity for platelet GP IIIa, vWF, and CD79a antigen in blast cells confirmed a diagnosis of M7 megakaryoblastic leukemia.

Original languageEnglish (US)
Pages (from-to)287-291
Number of pages5
JournalJournal of Veterinary Diagnostic Investigation
Volume18
Issue number3
DOIs
StatePublished - May 2006

Fingerprint

leukemia
Leukemia
Dogs
blood coagulation factors
dogs
von Willebrand Factor
CD79 Antigens
Blood Platelets
CD antigens
CD Antigens
Megakaryocyte Progenitor Cells
megakaryocytes
Integrin beta3
antibodies
Megakaryocytes
Antibodies
Paraffin
alkanes
Canidae
glycoproteins

Keywords

  • Anemia
  • Dog
  • Immunohistochemistry
  • M7
  • Megakaryoblastic leukemia
  • Pathology

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Clinical, histopathological and immunohistochemical findings in a case of megakaryoblastic leukemia in a dog. / Park, Hee Myung; Doster, Alan R; Tashbaeva, Roksana E.; Lee, Young Mee; Lyoo, Young S.; Lee, Sang Jin; Kim, Hee Jung; Sur, Jung Hyang.

In: Journal of Veterinary Diagnostic Investigation, Vol. 18, No. 3, 05.2006, p. 287-291.

Research output: Contribution to journalArticle

Park, Hee Myung ; Doster, Alan R ; Tashbaeva, Roksana E. ; Lee, Young Mee ; Lyoo, Young S. ; Lee, Sang Jin ; Kim, Hee Jung ; Sur, Jung Hyang. / Clinical, histopathological and immunohistochemical findings in a case of megakaryoblastic leukemia in a dog. In: Journal of Veterinary Diagnostic Investigation. 2006 ; Vol. 18, No. 3. pp. 287-291.
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