Clinical, histopathological and immunohistochemical findings in a case of megakaryoblastic leukemia in a dog

Hee Myung Park, Alan R Doster, Roksana E. Tashbaeva, Young Mee Lee, Young S. Lyoo, Sang Jin Lee, Hee Jung Kim, Jung Hyang Sur

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The clinical, hematological, and histopathologic features of megakaryoblastic leukemia (M7) were investigated in a 10-year-old female Shih-Tzu dog. Megakaryoblastic leukemia was diagnosed using antihuman platelet glycoprotein (GP IIIa) and anti-human von Willebrand factor (vWF) antibodies. The expression of CD antigen on megakaryoblasts was also assessed using a CD79a monoclonal antibody. Immunological markers allowed visualization of neoplastic megakaryocytes. Antibodies against platelet GP IIIa were demonstrated to be the most useful for the diagnosis of megakaryoblastic leukemia of paraffin-embedded canine tissues. Hematological and histological data coupled with immunohistochemical reactivity for platelet GP IIIa, vWF, and CD79a antigen in blast cells confirmed a diagnosis of M7 megakaryoblastic leukemia.

Original languageEnglish (US)
Pages (from-to)287-291
Number of pages5
JournalJournal of Veterinary Diagnostic Investigation
Volume18
Issue number3
DOIs
Publication statusPublished - May 2006

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Keywords

  • Anemia
  • Dog
  • Immunohistochemistry
  • M7
  • Megakaryoblastic leukemia
  • Pathology

ASJC Scopus subject areas

  • veterinary(all)

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