Clinical features and spectrum of light microscopic changes in interstitial cystitis

S. L. Johansson, M. Fall

Research output: Contribution to journalArticle

163 Citations (Scopus)

Abstract

Transurethral resection material from a series of 64 patients with classical (ulcer) interstitial cystitis (60 women and 4 men, with a mean age of 64 years), 44 with nonulcer interstitial cystitis (40 women and 4 men, with a mean age of 39 years) and 20 control women (mean age 49 years) were studied by light microscopy. Patients with classical disease had mucosal ulceration and hemorrhage, granulation tissue, intense inflammatory infiltrate, elevated mast cell counts and perineural infiltrates. Patients with nonulcer disease, despite the same severe symptoms, had a relatively unaltered mucosa with a sparse inflammatory response, the main feature being multiple, small, mucosal ruptures and suburothelial hemorrhages that were noted in a high proportion of the patients. It is suggested that these features are characteristic, specific and prevalent enough to allow for morphological differentiation of the 2 clinical subtypes of interstitial cystitis.

Original languageEnglish (US)
Pages (from-to)1118-1124
Number of pages7
JournalJournal of Urology
Volume143
Issue number6
DOIs
StatePublished - Jan 1 1990

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Interstitial Cystitis
Light
Hemorrhage
Granulation Tissue
Mast Cells
Ulcer
Rupture
Microscopy
Mucous Membrane
Cell Count

ASJC Scopus subject areas

  • Urology

Cite this

Clinical features and spectrum of light microscopic changes in interstitial cystitis. / Johansson, S. L.; Fall, M.

In: Journal of Urology, Vol. 143, No. 6, 01.01.1990, p. 1118-1124.

Research output: Contribution to journalArticle

Johansson, S. L. ; Fall, M. / Clinical features and spectrum of light microscopic changes in interstitial cystitis. In: Journal of Urology. 1990 ; Vol. 143, No. 6. pp. 1118-1124.
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