Clinical and immunologic characteristics of vibrio cholerae o139 bengal infection in north american volunteers

J. Glenn Morris, Genevieve E. Losonsky, Judith A. Johnson, Carol O. Tacket, James P. Nataro, Pinaki Panigrahi, Myron M. Levin

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Abstract

Vibrio cholerae O139 Bengal has recently emerged as a cause of epidemic cholera in Asia. To evaluate clinical and immunologic responses to infection, V. cholerae O139 Bengal AIl837 was administered to healthy adult North American volunteers. Two of 4 persons ingesting 104 cfu became ill (incubation period, 48 h; mean diarrheal stool, 1873 g), as did 7 of9 persons receiving 106 cfu (incubation period, 28 h; mean diarrheal stool, 4548 g). III volunteers did not demonstrate a vibriocidal antibody response to the challenge strain or other V. cholerae. Three months later, volunteers were rechallenged with the homologous O139 Bengal strain. Only 1 of 6 persons who had been ill on initial challenge had diarrhea, compared with 11 of 13 controls (P=.01; protective efficacy = 80%). V. cholerae O139 Bengal can cause severe diarrhea typical of cholera, with clinical characteristics and a dose-response similar to those seen with V. cholerae O1 E1 Tor. A moderately high level of protection against subsequent disease is provided by initial clinical infection.

Original languageEnglish (US)
Pages (from-to)903-908
Number of pages6
JournalJournal of Infectious Diseases
Volume171
Issue number4
DOIs
StatePublished - Jan 1 1995

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Vibrio cholerae O139
Volunteers
Cholera
Diarrhea
Infection
Vibrio cholerae O1
Vibrio cholerae
Antibody Formation

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

Cite this

Morris, J. G., Losonsky, G. E., Johnson, J. A., Tacket, C. O., Nataro, J. P., Panigrahi, P., & Levin, M. M. (1995). Clinical and immunologic characteristics of vibrio cholerae o139 bengal infection in north american volunteers. Journal of Infectious Diseases, 171(4), 903-908. https://doi.org/10.1093/infdis/171.4.903

Clinical and immunologic characteristics of vibrio cholerae o139 bengal infection in north american volunteers. / Morris, J. Glenn; Losonsky, Genevieve E.; Johnson, Judith A.; Tacket, Carol O.; Nataro, James P.; Panigrahi, Pinaki; Levin, Myron M.

In: Journal of Infectious Diseases, Vol. 171, No. 4, 01.01.1995, p. 903-908.

Research output: Contribution to journalArticle

Morris, JG, Losonsky, GE, Johnson, JA, Tacket, CO, Nataro, JP, Panigrahi, P & Levin, MM 1995, 'Clinical and immunologic characteristics of vibrio cholerae o139 bengal infection in north american volunteers', Journal of Infectious Diseases, vol. 171, no. 4, pp. 903-908. https://doi.org/10.1093/infdis/171.4.903
Morris, J. Glenn ; Losonsky, Genevieve E. ; Johnson, Judith A. ; Tacket, Carol O. ; Nataro, James P. ; Panigrahi, Pinaki ; Levin, Myron M. / Clinical and immunologic characteristics of vibrio cholerae o139 bengal infection in north american volunteers. In: Journal of Infectious Diseases. 1995 ; Vol. 171, No. 4. pp. 903-908.
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