Clinical and biologic hallmarks of the Philadelphia chromosome in childhood acute lymphoblastic leukemia

R. C. Ribeiro, M. Abromowitch, S. C. Raimondi, S. B. Murphy, F. Behm, D. L. Williams

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Abstract

Of 366 children with acute lymphoblastic leukemia (ALL) in whose bone marrow cells complete G-banding of chromosomes was successful, translocations were present at diagnosis in 141 (38.5%). The Philadelphia (Ph) chromosome was identified in 18 of these cases (4.9%). Features closely associated with the presence of the Ph chromosome were older age (median, 7.9 years), high leukocyte count (median, 47.3 x 109/L). French-American-British L1 blast cell morphology, high incidence of CNS leukemia at diagnosis, and the common ALL immunophenotype. All patients were treated according to modern chemotherapeutic regimens for ALL used at our institution. Complete remissions were successfully induced in only 13 (72%) of the 18 patients with Ph+ ALL, and only six remain free of leukemia for periods of 7+, 9+, 10+, 13+, 49+, and 70+ months. Our findings confirm the association of the Ph chromosome with classic high-risk features of ALL in children and suggest that this abnormality confers a very poor prognosis that has not yet been improved by modifications in established therapeutic regimens.

Original languageEnglish (US)
Pages (from-to)948-953
Number of pages6
JournalBlood
Volume70
Issue number4
StatePublished - Dec 1 1987

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Philadelphia Chromosome
Chromosomes
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Leukemia
Chromosomes, Human, 21-22 and Y
Chromosome Banding
Bone
Leukocyte Count
Bone Marrow Cells
Cells
Incidence

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Cite this

Ribeiro, R. C., Abromowitch, M., Raimondi, S. C., Murphy, S. B., Behm, F., & Williams, D. L. (1987). Clinical and biologic hallmarks of the Philadelphia chromosome in childhood acute lymphoblastic leukemia. Blood, 70(4), 948-953.

Clinical and biologic hallmarks of the Philadelphia chromosome in childhood acute lymphoblastic leukemia. / Ribeiro, R. C.; Abromowitch, M.; Raimondi, S. C.; Murphy, S. B.; Behm, F.; Williams, D. L.

In: Blood, Vol. 70, No. 4, 01.12.1987, p. 948-953.

Research output: Contribution to journalArticle

Ribeiro, RC, Abromowitch, M, Raimondi, SC, Murphy, SB, Behm, F & Williams, DL 1987, 'Clinical and biologic hallmarks of the Philadelphia chromosome in childhood acute lymphoblastic leukemia', Blood, vol. 70, no. 4, pp. 948-953.
Ribeiro RC, Abromowitch M, Raimondi SC, Murphy SB, Behm F, Williams DL. Clinical and biologic hallmarks of the Philadelphia chromosome in childhood acute lymphoblastic leukemia. Blood. 1987 Dec 1;70(4):948-953.
Ribeiro, R. C. ; Abromowitch, M. ; Raimondi, S. C. ; Murphy, S. B. ; Behm, F. ; Williams, D. L. / Clinical and biologic hallmarks of the Philadelphia chromosome in childhood acute lymphoblastic leukemia. In: Blood. 1987 ; Vol. 70, No. 4. pp. 948-953.
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N2 - Of 366 children with acute lymphoblastic leukemia (ALL) in whose bone marrow cells complete G-banding of chromosomes was successful, translocations were present at diagnosis in 141 (38.5%). The Philadelphia (Ph) chromosome was identified in 18 of these cases (4.9%). Features closely associated with the presence of the Ph chromosome were older age (median, 7.9 years), high leukocyte count (median, 47.3 x 109/L). French-American-British L1 blast cell morphology, high incidence of CNS leukemia at diagnosis, and the common ALL immunophenotype. All patients were treated according to modern chemotherapeutic regimens for ALL used at our institution. Complete remissions were successfully induced in only 13 (72%) of the 18 patients with Ph+ ALL, and only six remain free of leukemia for periods of 7+, 9+, 10+, 13+, 49+, and 70+ months. Our findings confirm the association of the Ph chromosome with classic high-risk features of ALL in children and suggest that this abnormality confers a very poor prognosis that has not yet been improved by modifications in established therapeutic regimens.

AB - Of 366 children with acute lymphoblastic leukemia (ALL) in whose bone marrow cells complete G-banding of chromosomes was successful, translocations were present at diagnosis in 141 (38.5%). The Philadelphia (Ph) chromosome was identified in 18 of these cases (4.9%). Features closely associated with the presence of the Ph chromosome were older age (median, 7.9 years), high leukocyte count (median, 47.3 x 109/L). French-American-British L1 blast cell morphology, high incidence of CNS leukemia at diagnosis, and the common ALL immunophenotype. All patients were treated according to modern chemotherapeutic regimens for ALL used at our institution. Complete remissions were successfully induced in only 13 (72%) of the 18 patients with Ph+ ALL, and only six remain free of leukemia for periods of 7+, 9+, 10+, 13+, 49+, and 70+ months. Our findings confirm the association of the Ph chromosome with classic high-risk features of ALL in children and suggest that this abnormality confers a very poor prognosis that has not yet been improved by modifications in established therapeutic regimens.

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