Click-connected ligand scaffolds: macrocyclic chelates for asymmetric hydrogenation

Zhang Qing, James M. Takacs

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Click chemistry is used to construct ligand scaffolds for a series of chiral diphosphites. Enantioselectivity as high as 97% ee is obtained using these click ligands in rhodium-catalyzed asymmetric hydrogenation. Control experiments and spectroscopic data suggest that a 16-membered P,P-macrocyclic Rh(1) chelate is formed.

Original languageEnglish (US)
Pages (from-to)545-548
Number of pages4
JournalOrganic Letters
Volume10
Issue number4
DOIs
StatePublished - Feb 21 2008

Fingerprint

Hydrogenation
chelates
Scaffolds
hydrogenation
Click Chemistry
Ligands
Rhodium
ligands
Enantioselectivity
rhodium
chemistry
Experiments

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Click-connected ligand scaffolds : macrocyclic chelates for asymmetric hydrogenation. / Qing, Zhang; Takacs, James M.

In: Organic Letters, Vol. 10, No. 4, 21.02.2008, p. 545-548.

Research output: Contribution to journalArticle

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