Click chemistry, a powerful tool for pharmaceutical sciences

Christopher D. Hein, Xin Ming Liu, Dong Wang

Research output: Contribution to journalReview article

434 Citations (Scopus)

Abstract

Click chemistry refers to a group of reactions that are fast, simple to use, easy to purify, versatile, regiospecific, and give high product yields. While there are a number of reactions that fulfill the criteria, the Huisgen 1,3-dipolar cycloaddition of azides and terminal alkynes has emerged as the frontrunner. It has found applications in a wide variety of research areas, including materials sciences, polymer chemistry, and pharmaceutical sciences. In this manuscript, important aspects of the Huisgen cycloaddition will be reviewed, along with some of its many pharmaceutical applications. Bioconjugation, nanoparticle surface modification, and pharmaceutical-related polymer chemistry will all be covered. Limitations of the reaction will also be discussed.

Original languageEnglish (US)
Pages (from-to)2216-2230
Number of pages15
JournalPharmaceutical Research
Volume25
Issue number10
DOIs
StatePublished - Oct 1 2008

Fingerprint

Click Chemistry
Cycloaddition Reaction
Polymers
Cycloaddition
Alkynes
Azides
Pharmaceutical Chemistry
Pharmaceutical Preparations
Nanoparticles
Materials science
Surface treatment
Research

Keywords

  • Bioconjugation
  • Click chemistry
  • Drug delivery
  • Nanomedicine
  • Polymer

ASJC Scopus subject areas

  • Biotechnology
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Organic Chemistry
  • Pharmacology (medical)

Cite this

Click chemistry, a powerful tool for pharmaceutical sciences. / Hein, Christopher D.; Liu, Xin Ming; Wang, Dong.

In: Pharmaceutical Research, Vol. 25, No. 10, 01.10.2008, p. 2216-2230.

Research output: Contribution to journalReview article

Hein, Christopher D. ; Liu, Xin Ming ; Wang, Dong. / Click chemistry, a powerful tool for pharmaceutical sciences. In: Pharmaceutical Research. 2008 ; Vol. 25, No. 10. pp. 2216-2230.
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