Clear cell sarcoma of soft tissue metastatic to the ovaries: A heretofore unreported occurrence

Summer L. Nugent, Daniel C. Dim, Julia A. Bridge, Olga B. Ioffe

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Clear cell sarcoma of soft tissue (CCSST) is a rare soft tissue neoplasm with marked variable tumor progression and prognosis. Although morphologically similar to malignant melanoma, CCSST can be distinguished by the presence of a t(12; 22)(q13; q12) and/or associated EWSR1-ATF1 chimeric gene. CCSST has an affinity for the extremities and is capable of metastasizing to a wide variety of sites including bone, lung, and lymph nodes and rarely to skin, liver, heart, muscle, and brain. Metastases have been known to occur as late as 29 years after initial presentation. We report a case of a 33-year-old woman who presented with bilateral ovarian cystic tumors, ascites, and pulmonary nodules. Her past medical history was significant for clear cell sarcoma of the left foot 2 years earlier. Bilateral salpingo-oophorectomy was performed and the light microscopic and immunohistochemical findings coupled with the detection of an EWSR1 rearrangement by fluorescence in situ hybridization were compatible with a diagnosis of CCSST metastases to the ovaries. To the best of our knowledge, this is the first reported case of CCSST metastatic to the ovaries.

Original languageEnglish (US)
Pages (from-to)234-238
Number of pages5
JournalInternational Journal of Gynecological Pathology
Volume28
Issue number3
DOIs
StatePublished - May 1 2009

Fingerprint

Clear Cell Sarcoma
Ovary
Soft Tissue Neoplasms
Neoplasm Metastasis
Lung
Ovariectomy
Fluorescence In Situ Hybridization
Ascites
Foot
Melanoma
Neoplasms
Myocardium
Extremities
Lymph Nodes
Light
Bone and Bones
Skin
Liver
Brain
Genes

Keywords

  • Clear cell sarcoma of soft tissue
  • Malignant melanoma of soft parts
  • Metastasis
  • Molecular cytogenetics
  • Ovary-

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Obstetrics and Gynecology

Cite this

Clear cell sarcoma of soft tissue metastatic to the ovaries : A heretofore unreported occurrence. / Nugent, Summer L.; Dim, Daniel C.; Bridge, Julia A.; Ioffe, Olga B.

In: International Journal of Gynecological Pathology, Vol. 28, No. 3, 01.05.2009, p. 234-238.

Research output: Contribution to journalArticle

Nugent, Summer L. ; Dim, Daniel C. ; Bridge, Julia A. ; Ioffe, Olga B. / Clear cell sarcoma of soft tissue metastatic to the ovaries : A heretofore unreported occurrence. In: International Journal of Gynecological Pathology. 2009 ; Vol. 28, No. 3. pp. 234-238.
@article{0702eb664ab249edbfbf42341620dca9,
title = "Clear cell sarcoma of soft tissue metastatic to the ovaries: A heretofore unreported occurrence",
abstract = "Clear cell sarcoma of soft tissue (CCSST) is a rare soft tissue neoplasm with marked variable tumor progression and prognosis. Although morphologically similar to malignant melanoma, CCSST can be distinguished by the presence of a t(12; 22)(q13; q12) and/or associated EWSR1-ATF1 chimeric gene. CCSST has an affinity for the extremities and is capable of metastasizing to a wide variety of sites including bone, lung, and lymph nodes and rarely to skin, liver, heart, muscle, and brain. Metastases have been known to occur as late as 29 years after initial presentation. We report a case of a 33-year-old woman who presented with bilateral ovarian cystic tumors, ascites, and pulmonary nodules. Her past medical history was significant for clear cell sarcoma of the left foot 2 years earlier. Bilateral salpingo-oophorectomy was performed and the light microscopic and immunohistochemical findings coupled with the detection of an EWSR1 rearrangement by fluorescence in situ hybridization were compatible with a diagnosis of CCSST metastases to the ovaries. To the best of our knowledge, this is the first reported case of CCSST metastatic to the ovaries.",
keywords = "Clear cell sarcoma of soft tissue, Malignant melanoma of soft parts, Metastasis, Molecular cytogenetics, Ovary-",
author = "Nugent, {Summer L.} and Dim, {Daniel C.} and Bridge, {Julia A.} and Ioffe, {Olga B.}",
year = "2009",
month = "5",
day = "1",
doi = "10.1097/PGP.0b013e31818d10a8",
language = "English (US)",
volume = "28",
pages = "234--238",
journal = "International Journal of Gynecological Pathology",
issn = "0277-1691",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Clear cell sarcoma of soft tissue metastatic to the ovaries

T2 - A heretofore unreported occurrence

AU - Nugent, Summer L.

AU - Dim, Daniel C.

AU - Bridge, Julia A.

AU - Ioffe, Olga B.

PY - 2009/5/1

Y1 - 2009/5/1

N2 - Clear cell sarcoma of soft tissue (CCSST) is a rare soft tissue neoplasm with marked variable tumor progression and prognosis. Although morphologically similar to malignant melanoma, CCSST can be distinguished by the presence of a t(12; 22)(q13; q12) and/or associated EWSR1-ATF1 chimeric gene. CCSST has an affinity for the extremities and is capable of metastasizing to a wide variety of sites including bone, lung, and lymph nodes and rarely to skin, liver, heart, muscle, and brain. Metastases have been known to occur as late as 29 years after initial presentation. We report a case of a 33-year-old woman who presented with bilateral ovarian cystic tumors, ascites, and pulmonary nodules. Her past medical history was significant for clear cell sarcoma of the left foot 2 years earlier. Bilateral salpingo-oophorectomy was performed and the light microscopic and immunohistochemical findings coupled with the detection of an EWSR1 rearrangement by fluorescence in situ hybridization were compatible with a diagnosis of CCSST metastases to the ovaries. To the best of our knowledge, this is the first reported case of CCSST metastatic to the ovaries.

AB - Clear cell sarcoma of soft tissue (CCSST) is a rare soft tissue neoplasm with marked variable tumor progression and prognosis. Although morphologically similar to malignant melanoma, CCSST can be distinguished by the presence of a t(12; 22)(q13; q12) and/or associated EWSR1-ATF1 chimeric gene. CCSST has an affinity for the extremities and is capable of metastasizing to a wide variety of sites including bone, lung, and lymph nodes and rarely to skin, liver, heart, muscle, and brain. Metastases have been known to occur as late as 29 years after initial presentation. We report a case of a 33-year-old woman who presented with bilateral ovarian cystic tumors, ascites, and pulmonary nodules. Her past medical history was significant for clear cell sarcoma of the left foot 2 years earlier. Bilateral salpingo-oophorectomy was performed and the light microscopic and immunohistochemical findings coupled with the detection of an EWSR1 rearrangement by fluorescence in situ hybridization were compatible with a diagnosis of CCSST metastases to the ovaries. To the best of our knowledge, this is the first reported case of CCSST metastatic to the ovaries.

KW - Clear cell sarcoma of soft tissue

KW - Malignant melanoma of soft parts

KW - Metastasis

KW - Molecular cytogenetics

KW - Ovary-

UR - http://www.scopus.com/inward/record.url?scp=69049099971&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=69049099971&partnerID=8YFLogxK

U2 - 10.1097/PGP.0b013e31818d10a8

DO - 10.1097/PGP.0b013e31818d10a8

M3 - Article

C2 - 19620941

AN - SCOPUS:69049099971

VL - 28

SP - 234

EP - 238

JO - International Journal of Gynecological Pathology

JF - International Journal of Gynecological Pathology

SN - 0277-1691

IS - 3

ER -