Claudin proteins, outside-in signaling, and carcinogenesis

Amar Bahadur Singh, Srijayaprakash B. Uppada, Punita Dhawan

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

Environment affects an individual’s development and disease risk which then suggest that the environmental cues must have ways of reaching to the cellular nuclei to orchestrate desired genetic changes. Polarized and differentiated epithelial cells join together by cell-cell adhesions to create a protective sheet which separates body’s internal milieu from its environment, albeit in highly regulated manner. Among these cell-cell adhesions, a key role of tight junction, the apical cell-cell adhesion, in maintaining epithelial cell polarity and differentiation is well recognized. Moreover, significant changes in expression and cellular distribution of claudin proteins, integral component of the tight junction, characterize pathophysiological changes including neoplastic growth and progression. Studies have further confirmed existence of complex claudin-based interactomes and demonstrated that changes in such protein partnering can influence barrier integrity and communication between a cell and its environment to produce undesired outcome. Cell signaling is the process by which cells respond to their environment to make dynamic decisions to live, grow and proliferate, or die. Thus, pivotal role of the deregulated tight junction structure/function in influencing cellular signaling cascades to alter cellular phenotype can be envisaged, however, is not well understood. Needless to mention that advanced knowledge in this area can help improve therapeutic considerations and preventive measures. Here, we discuss potential role of the tight junction in the regulation of “outside-in” signaling to regulate cancer growth, with specific focus upon the claudin family of proteins.

Original languageEnglish (US)
Pages (from-to)69-75
Number of pages7
JournalPflugers Archiv European Journal of Physiology
Volume469
Issue number1
DOIs
StatePublished - Jan 1 2017

Fingerprint

Claudins
Cell adhesion
Cell signaling
Carcinogenesis
Tight Junctions
Cell Adhesion
Proteins
Epithelial Cells
Communication Barriers
Cell Polarity
Communication
Growth
Cues
Cell Differentiation
Phenotype

Keywords

  • Cancer progression
  • Claudin
  • Signaling
  • Stem cell
  • Tight junction

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Physiology (medical)

Cite this

Claudin proteins, outside-in signaling, and carcinogenesis. / Singh, Amar Bahadur; Uppada, Srijayaprakash B.; Dhawan, Punita.

In: Pflugers Archiv European Journal of Physiology, Vol. 469, No. 1, 01.01.2017, p. 69-75.

Research output: Contribution to journalReview article

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