Classification schemes for carcinogenicity based on hazard-identification have become outmoded and serve neither science nor society

Alan R. Boobis, Samuel Monroe Cohen, Vicki L. Dellarco, John E. Doe, Penelope A. Fenner-Crisp, Angelo Moretto, Timothy P. Pastoor, Rita S. Schoeny, Jennifer G. Seed, Douglas C. Wolf

Research output: Contribution to journalComment/debate

24 Citations (Scopus)

Abstract

Classification schemes for carcinogenicity based solely on hazard-identification such as the IARC monograph process and the UN system adopted in the EU have become outmoded. They are based on a concept developed in the 1970s that chemicals could be divided into two classes: carcinogens and non-carcinogens. Categorization in this way places into the same category chemicals and agents with widely differing potencies and modes of action. This is how eating processed meat can fall into the same category as sulfur mustard gas. Approaches based on hazard and risk characterization present an integrated and balanced picture of hazard, dose response and exposure and allow informed risk management decisions to be taken. Because a risk-based decision framework fully considers hazard in the context of dose, potency, and exposure the unintended downsides of a hazard only approach are avoided, e.g., health scares, unnecessary economic costs, loss of beneficial products, adoption of strategies with greater health costs, and the diversion of public funds into unnecessary research. An initiative to agree upon a standardized, internationally acceptable methodology for carcinogen assessment is needed now. The approach should incorporate principles and concepts of existing international consensus-based frameworks including the WHO IPCS mode of action framework.

Original languageEnglish (US)
Pages (from-to)158-166
Number of pages9
JournalRegulatory Toxicology and Pharmacology
Volume82
DOIs
StatePublished - Dec 1 2016

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Mustard Gas
Carcinogens
Hazards
United Nations
Risk Management
Financial Management
Health Care Costs
Meat
Eating
Economics
Costs and Cost Analysis
Health
Research
Meats
Risk management
Costs

Keywords

  • Carcinogenicity
  • Classification
  • GHS
  • Hazard characterization
  • IARC
  • Risk assessment

ASJC Scopus subject areas

  • Toxicology

Cite this

Classification schemes for carcinogenicity based on hazard-identification have become outmoded and serve neither science nor society. / Boobis, Alan R.; Cohen, Samuel Monroe; Dellarco, Vicki L.; Doe, John E.; Fenner-Crisp, Penelope A.; Moretto, Angelo; Pastoor, Timothy P.; Schoeny, Rita S.; Seed, Jennifer G.; Wolf, Douglas C.

In: Regulatory Toxicology and Pharmacology, Vol. 82, 01.12.2016, p. 158-166.

Research output: Contribution to journalComment/debate

Boobis, Alan R. ; Cohen, Samuel Monroe ; Dellarco, Vicki L. ; Doe, John E. ; Fenner-Crisp, Penelope A. ; Moretto, Angelo ; Pastoor, Timothy P. ; Schoeny, Rita S. ; Seed, Jennifer G. ; Wolf, Douglas C. / Classification schemes for carcinogenicity based on hazard-identification have become outmoded and serve neither science nor society. In: Regulatory Toxicology and Pharmacology. 2016 ; Vol. 82. pp. 158-166.
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