Classification of rhabdomyosarcomas and related sarcomas. Pathologic aspects and proposal for a new classification‐an intergroup rhabdomyosarcoma study

William A. Newton, Edmund A. Gehan, Bruce L. Webber, Henry B. Marsden, A. J.M. van Unnik, Ala B. Hamoudi, Maria C. Tsokos, Hiroyuki Shimada, Dieter Harms, Dietmar Schmidt, Vito Ninfo, Andrea O. Cavazzana, Frank Gonzalez‐Crussi, David M. Parham, Herbert M. Reiman, Lina Asmar, Mohan S. Beltangady, Nancy E. Sachs, Timothy J. Triche, Harold M. Maurer

Research output: Contribution to journalArticle

407 Citations (Scopus)

Abstract

Background. There is a need to develop a single prognostically significant classification of rhabdomyosarcomas (RMS) and other related tumors of children, adolescents, and young adults which would be a current guide for their diagnosis, allow valid comparison of outcomes between protocols carried out anywhere in the world, and should enhance recognition of prognostic subsets. Method. Sixteen pathologists from eight pathology groups, representing six countries and several cooperative groups, classified by four histopathologic classification schemes 800 representative tumors of the 999 eligible cases treated on Intergroup Rhabdomyosarcoma Study II. Each tumor was classified according to each of the four systems by each of the pathologists. In addition, two independent subsamples of 200 of the 800 patients were reviewed according to the new system, so that 343 distinct patients were reviewed once, and 57 of these twice. Results. A study of the survival rates of all subtypes in the sample of 800 patients led to the formation of a new system. This was tested on two independent subsets of 200 of the original cases and found to be reproducible and predictive of outcome by univariate analysis. A multivariate analysis of the 343 patients classified according to the new system indicated that a survival model including pathologic classification and known prognostic factors of primary site, clinical group, and tumor size was significantly better at predicting survival than a model with only the known prognostic factors. Conclusion. This new classification, termed International Classification of Rhabdomyosarcoma (ICR) by the authors, was reproducible and predictive of outcome among patients with differing histologies treated uniformly on the Intergroup Rhabdomyosarcoma II protocols. We believe it should be utilized by all pathologists and cooperative groups to classify rhabdomyosarcomas in order to provide comparability among and within multi‐institutional studies. Cancer 1995;76:1073‐85.

Original languageEnglish (US)
Pages (from-to)1073-1085
Number of pages13
JournalCancer
Volume76
Issue number6
DOIs
StatePublished - Sep 15 1995

Fingerprint

Rhabdomyosarcoma
Sarcoma
Neoplasms
Survival
Young Adult
Histology
Multivariate Analysis
Survival Rate
Pathology
Pathologists

Keywords

  • adolescents
  • children
  • rhabdomyosarcoma
  • soft tissue sarcoma
  • tumor classification

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Classification of rhabdomyosarcomas and related sarcomas. Pathologic aspects and proposal for a new classification‐an intergroup rhabdomyosarcoma study. / Newton, William A.; Gehan, Edmund A.; Webber, Bruce L.; Marsden, Henry B.; van Unnik, A. J.M.; Hamoudi, Ala B.; Tsokos, Maria C.; Shimada, Hiroyuki; Harms, Dieter; Schmidt, Dietmar; Ninfo, Vito; Cavazzana, Andrea O.; Gonzalez‐Crussi, Frank; Parham, David M.; Reiman, Herbert M.; Asmar, Lina; Beltangady, Mohan S.; Sachs, Nancy E.; Triche, Timothy J.; Maurer, Harold M.

In: Cancer, Vol. 76, No. 6, 15.09.1995, p. 1073-1085.

Research output: Contribution to journalArticle

Newton, WA, Gehan, EA, Webber, BL, Marsden, HB, van Unnik, AJM, Hamoudi, AB, Tsokos, MC, Shimada, H, Harms, D, Schmidt, D, Ninfo, V, Cavazzana, AO, Gonzalez‐Crussi, F, Parham, DM, Reiman, HM, Asmar, L, Beltangady, MS, Sachs, NE, Triche, TJ & Maurer, HM 1995, 'Classification of rhabdomyosarcomas and related sarcomas. Pathologic aspects and proposal for a new classification‐an intergroup rhabdomyosarcoma study', Cancer, vol. 76, no. 6, pp. 1073-1085. https://doi.org/10.1002/1097-0142(19950915)76:6<1073::AID-CNCR2820760624>3.0.CO;2-L
Newton, William A. ; Gehan, Edmund A. ; Webber, Bruce L. ; Marsden, Henry B. ; van Unnik, A. J.M. ; Hamoudi, Ala B. ; Tsokos, Maria C. ; Shimada, Hiroyuki ; Harms, Dieter ; Schmidt, Dietmar ; Ninfo, Vito ; Cavazzana, Andrea O. ; Gonzalez‐Crussi, Frank ; Parham, David M. ; Reiman, Herbert M. ; Asmar, Lina ; Beltangady, Mohan S. ; Sachs, Nancy E. ; Triche, Timothy J. ; Maurer, Harold M. / Classification of rhabdomyosarcomas and related sarcomas. Pathologic aspects and proposal for a new classification‐an intergroup rhabdomyosarcoma study. In: Cancer. 1995 ; Vol. 76, No. 6. pp. 1073-1085.
@article{95a1cea631344eba8046f8e2044a1a0f,
title = "Classification of rhabdomyosarcomas and related sarcomas. Pathologic aspects and proposal for a new classification‐an intergroup rhabdomyosarcoma study",
abstract = "Background. There is a need to develop a single prognostically significant classification of rhabdomyosarcomas (RMS) and other related tumors of children, adolescents, and young adults which would be a current guide for their diagnosis, allow valid comparison of outcomes between protocols carried out anywhere in the world, and should enhance recognition of prognostic subsets. Method. Sixteen pathologists from eight pathology groups, representing six countries and several cooperative groups, classified by four histopathologic classification schemes 800 representative tumors of the 999 eligible cases treated on Intergroup Rhabdomyosarcoma Study II. Each tumor was classified according to each of the four systems by each of the pathologists. In addition, two independent subsamples of 200 of the 800 patients were reviewed according to the new system, so that 343 distinct patients were reviewed once, and 57 of these twice. Results. A study of the survival rates of all subtypes in the sample of 800 patients led to the formation of a new system. This was tested on two independent subsets of 200 of the original cases and found to be reproducible and predictive of outcome by univariate analysis. A multivariate analysis of the 343 patients classified according to the new system indicated that a survival model including pathologic classification and known prognostic factors of primary site, clinical group, and tumor size was significantly better at predicting survival than a model with only the known prognostic factors. Conclusion. This new classification, termed International Classification of Rhabdomyosarcoma (ICR) by the authors, was reproducible and predictive of outcome among patients with differing histologies treated uniformly on the Intergroup Rhabdomyosarcoma II protocols. We believe it should be utilized by all pathologists and cooperative groups to classify rhabdomyosarcomas in order to provide comparability among and within multi‐institutional studies. Cancer 1995;76:1073‐85.",
keywords = "adolescents, children, rhabdomyosarcoma, soft tissue sarcoma, tumor classification",
author = "Newton, {William A.} and Gehan, {Edmund A.} and Webber, {Bruce L.} and Marsden, {Henry B.} and {van Unnik}, {A. J.M.} and Hamoudi, {Ala B.} and Tsokos, {Maria C.} and Hiroyuki Shimada and Dieter Harms and Dietmar Schmidt and Vito Ninfo and Cavazzana, {Andrea O.} and Frank Gonzalez‐Crussi and Parham, {David M.} and Reiman, {Herbert M.} and Lina Asmar and Beltangady, {Mohan S.} and Sachs, {Nancy E.} and Triche, {Timothy J.} and Maurer, {Harold M.}",
year = "1995",
month = "9",
day = "15",
doi = "10.1002/1097-0142(19950915)76:6<1073::AID-CNCR2820760624>3.0.CO;2-L",
language = "English (US)",
volume = "76",
pages = "1073--1085",
journal = "Cancer",
issn = "0008-543X",
publisher = "John Wiley and Sons Inc.",
number = "6",

}

TY - JOUR

T1 - Classification of rhabdomyosarcomas and related sarcomas. Pathologic aspects and proposal for a new classification‐an intergroup rhabdomyosarcoma study

AU - Newton, William A.

AU - Gehan, Edmund A.

AU - Webber, Bruce L.

AU - Marsden, Henry B.

AU - van Unnik, A. J.M.

AU - Hamoudi, Ala B.

AU - Tsokos, Maria C.

AU - Shimada, Hiroyuki

AU - Harms, Dieter

AU - Schmidt, Dietmar

AU - Ninfo, Vito

AU - Cavazzana, Andrea O.

AU - Gonzalez‐Crussi, Frank

AU - Parham, David M.

AU - Reiman, Herbert M.

AU - Asmar, Lina

AU - Beltangady, Mohan S.

AU - Sachs, Nancy E.

AU - Triche, Timothy J.

AU - Maurer, Harold M.

PY - 1995/9/15

Y1 - 1995/9/15

N2 - Background. There is a need to develop a single prognostically significant classification of rhabdomyosarcomas (RMS) and other related tumors of children, adolescents, and young adults which would be a current guide for their diagnosis, allow valid comparison of outcomes between protocols carried out anywhere in the world, and should enhance recognition of prognostic subsets. Method. Sixteen pathologists from eight pathology groups, representing six countries and several cooperative groups, classified by four histopathologic classification schemes 800 representative tumors of the 999 eligible cases treated on Intergroup Rhabdomyosarcoma Study II. Each tumor was classified according to each of the four systems by each of the pathologists. In addition, two independent subsamples of 200 of the 800 patients were reviewed according to the new system, so that 343 distinct patients were reviewed once, and 57 of these twice. Results. A study of the survival rates of all subtypes in the sample of 800 patients led to the formation of a new system. This was tested on two independent subsets of 200 of the original cases and found to be reproducible and predictive of outcome by univariate analysis. A multivariate analysis of the 343 patients classified according to the new system indicated that a survival model including pathologic classification and known prognostic factors of primary site, clinical group, and tumor size was significantly better at predicting survival than a model with only the known prognostic factors. Conclusion. This new classification, termed International Classification of Rhabdomyosarcoma (ICR) by the authors, was reproducible and predictive of outcome among patients with differing histologies treated uniformly on the Intergroup Rhabdomyosarcoma II protocols. We believe it should be utilized by all pathologists and cooperative groups to classify rhabdomyosarcomas in order to provide comparability among and within multi‐institutional studies. Cancer 1995;76:1073‐85.

AB - Background. There is a need to develop a single prognostically significant classification of rhabdomyosarcomas (RMS) and other related tumors of children, adolescents, and young adults which would be a current guide for their diagnosis, allow valid comparison of outcomes between protocols carried out anywhere in the world, and should enhance recognition of prognostic subsets. Method. Sixteen pathologists from eight pathology groups, representing six countries and several cooperative groups, classified by four histopathologic classification schemes 800 representative tumors of the 999 eligible cases treated on Intergroup Rhabdomyosarcoma Study II. Each tumor was classified according to each of the four systems by each of the pathologists. In addition, two independent subsamples of 200 of the 800 patients were reviewed according to the new system, so that 343 distinct patients were reviewed once, and 57 of these twice. Results. A study of the survival rates of all subtypes in the sample of 800 patients led to the formation of a new system. This was tested on two independent subsets of 200 of the original cases and found to be reproducible and predictive of outcome by univariate analysis. A multivariate analysis of the 343 patients classified according to the new system indicated that a survival model including pathologic classification and known prognostic factors of primary site, clinical group, and tumor size was significantly better at predicting survival than a model with only the known prognostic factors. Conclusion. This new classification, termed International Classification of Rhabdomyosarcoma (ICR) by the authors, was reproducible and predictive of outcome among patients with differing histologies treated uniformly on the Intergroup Rhabdomyosarcoma II protocols. We believe it should be utilized by all pathologists and cooperative groups to classify rhabdomyosarcomas in order to provide comparability among and within multi‐institutional studies. Cancer 1995;76:1073‐85.

KW - adolescents

KW - children

KW - rhabdomyosarcoma

KW - soft tissue sarcoma

KW - tumor classification

UR - http://www.scopus.com/inward/record.url?scp=0028978780&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028978780&partnerID=8YFLogxK

U2 - 10.1002/1097-0142(19950915)76:6<1073::AID-CNCR2820760624>3.0.CO;2-L

DO - 10.1002/1097-0142(19950915)76:6<1073::AID-CNCR2820760624>3.0.CO;2-L

M3 - Article

C2 - 8625211

AN - SCOPUS:0028978780

VL - 76

SP - 1073

EP - 1085

JO - Cancer

JF - Cancer

SN - 0008-543X

IS - 6

ER -