Classification of non-Hodgkin lymphoma in South-eastern Europe: Review of 632 cases from the international non-Hodgkin lymphoma classification project

Snjezana Dotlic, Anamarija M. Perry, Gordana Petrusevska, Bogdan Fetica, Jacques Diebold, Kenneth A. Maclennan, Hans K. Müller-Hermelink, Bharat N. Nathwani, Eugene Boilesen, Martin Bast, James Olen Armitage, Dennis D. Weisenburger

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The distribution of non-Hodgkin lymphoma (NHL) subtypes varies around the world, but a systematic study of South-eastern Europe (SEEU) has never been done. Therefore, we evaluated the relative frequencies of NHL subtypes in three SEEU countries - Croatia, Romania and Macedonia. Five expert haematopathologists reviewed 632 consecutive cases of newly diagnosed NHL from the three SEEU countries using the World Health Organization classification. The results were compared to 399 cases from North America (NA) and 580 cases from Western Europe (WEU). The proportions of B- and T-cell NHL and the sex distribution in SEEU were similar to WEU and NA. However, the median ages of patients with low- and high-grade B-NHL in SEEU (60 and 59 years, respectively) were significantly lower than in NA (64 and 68 years, respectively; P < 0·05). SEEU had a significantly lower proportion of low-grade B-NHL (46·6%) and higher proportion of high-grade B-NHL (44·5%) compared to both WEU (54·5% and 36·4%, respectively) and NA (56·1% and 34·3%, respectively). There were no significant differences in the relative frequencies of T-NHL subtypes. This study provides new insights into differences in the relative frequencies of NHL subtypes in different geographic regions. Epidemiological studies are needed to better characterize and explain these differences.

Original languageEnglish (US)
Pages (from-to)366-372
Number of pages7
JournalBritish Journal of Haematology
Volume171
Issue number3
DOIs
StatePublished - Nov 2015

Fingerprint

Eastern Europe
Non-Hodgkin's Lymphoma
North America
Romania
Sex Distribution
Croatia
T-Cell Lymphoma
Epidemiologic Studies

Keywords

  • Croatia
  • Macedonia
  • Non-Hodgkin lymphoma
  • Romania
  • South-eastern Europe

ASJC Scopus subject areas

  • Hematology

Cite this

Classification of non-Hodgkin lymphoma in South-eastern Europe : Review of 632 cases from the international non-Hodgkin lymphoma classification project. / Dotlic, Snjezana; Perry, Anamarija M.; Petrusevska, Gordana; Fetica, Bogdan; Diebold, Jacques; Maclennan, Kenneth A.; Müller-Hermelink, Hans K.; Nathwani, Bharat N.; Boilesen, Eugene; Bast, Martin; Armitage, James Olen; Weisenburger, Dennis D.

In: British Journal of Haematology, Vol. 171, No. 3, 11.2015, p. 366-372.

Research output: Contribution to journalArticle

Dotlic, S, Perry, AM, Petrusevska, G, Fetica, B, Diebold, J, Maclennan, KA, Müller-Hermelink, HK, Nathwani, BN, Boilesen, E, Bast, M, Armitage, JO & Weisenburger, DD 2015, 'Classification of non-Hodgkin lymphoma in South-eastern Europe: Review of 632 cases from the international non-Hodgkin lymphoma classification project', British Journal of Haematology, vol. 171, no. 3, pp. 366-372. https://doi.org/10.1111/bjh.13586
Dotlic, Snjezana ; Perry, Anamarija M. ; Petrusevska, Gordana ; Fetica, Bogdan ; Diebold, Jacques ; Maclennan, Kenneth A. ; Müller-Hermelink, Hans K. ; Nathwani, Bharat N. ; Boilesen, Eugene ; Bast, Martin ; Armitage, James Olen ; Weisenburger, Dennis D. / Classification of non-Hodgkin lymphoma in South-eastern Europe : Review of 632 cases from the international non-Hodgkin lymphoma classification project. In: British Journal of Haematology. 2015 ; Vol. 171, No. 3. pp. 366-372.
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