Classification and clinical course of low-grade non-Hodgkin's lymphomas with overview of therapy

Research output: Contribution to journalReview article

16 Citations (Scopus)

Abstract

Low-grade non-Hodgkin's lymphoma (NHL) presents a formidable treatment challenge to oncologists. This review evaluates the various methods of disease and patient management. The natural history of various subtypes of low-grade NHL and the classification according to the National Cancer Institute Working Formulation are discussed in this review. Additionally, the various therapies in use; radiotherapy alone and combined with chemotherapy, chemotherapy with single alkylating agents such as chlorambucil and combination therapies, autologous and allogenic bone marrow transplantation, and therapy with purine analogs, such as chlorodeoxyadenosine and fludarabine. Patient survival in various studies using these treatment modalities are discussed. Treatment options need to be combined with the use of prognostic models, such as the International Index for optimal care of this difficult-to-treat group of patients.

Original languageEnglish (US)
Pages (from-to)13-19
Number of pages7
JournalAnnals of Oncology
Volume7
Issue numberSUPPL. 6
StatePublished - Dec 1 1996

Fingerprint

Non-Hodgkin's Lymphoma
Therapeutics
Chlorambucil
Drug Therapy
National Cancer Institute (U.S.)
Alkylating Agents
Homologous Transplantation
Disease Management
Natural History
Bone Marrow Transplantation
Radiotherapy
Survival

Keywords

  • bone marrow transplantation
  • chemotherapy
  • non-Hodgkin's lymphoma
  • purine analogs
  • radiotherapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Classification and clinical course of low-grade non-Hodgkin's lymphomas with overview of therapy. / Vose, Julie Marie.

In: Annals of Oncology, Vol. 7, No. SUPPL. 6, 01.12.1996, p. 13-19.

Research output: Contribution to journalReview article

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