Cisplatin-induced changes in bleomycin elimination

Gary C Yee, W. R. Crom, J. E. Champion, G. M. Brodeur, W. E. Evans

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Bleomycin disposition was studied in two children who received at least six courses of vinblastine, bleomycin, and cisplatin. Total plasma clearance of bleomycin decreased from 39 to 18 ml/min/m2, while the terminal-phase half-life increased from 4.4 to 6.0 hrs since the cumulative cisplatin dose was > 300 mg/m2. In one patient, renal clearance of bleomycin decreased from 30 to 8.2 ml/min/m2. Changes in serum creatinine on BUN were not predictive of changes in bleomycin elimination.

Original languageEnglish (US)
Pages (from-to)587-589
Number of pages3
JournalCancer Treatment Reports
Volume67
Issue number6
StatePublished - Sep 1 1983

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Bleomycin
Cisplatin
Vinblastine
Blood Urea Nitrogen
Half-Life
Creatinine
Kidney
indium-bleomycin
Serum

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Yee, G. C., Crom, W. R., Champion, J. E., Brodeur, G. M., & Evans, W. E. (1983). Cisplatin-induced changes in bleomycin elimination. Cancer Treatment Reports, 67(6), 587-589.

Cisplatin-induced changes in bleomycin elimination. / Yee, Gary C; Crom, W. R.; Champion, J. E.; Brodeur, G. M.; Evans, W. E.

In: Cancer Treatment Reports, Vol. 67, No. 6, 01.09.1983, p. 587-589.

Research output: Contribution to journalArticle

Yee, GC, Crom, WR, Champion, JE, Brodeur, GM & Evans, WE 1983, 'Cisplatin-induced changes in bleomycin elimination', Cancer Treatment Reports, vol. 67, no. 6, pp. 587-589.
Yee GC, Crom WR, Champion JE, Brodeur GM, Evans WE. Cisplatin-induced changes in bleomycin elimination. Cancer Treatment Reports. 1983 Sep 1;67(6):587-589.
Yee, Gary C ; Crom, W. R. ; Champion, J. E. ; Brodeur, G. M. ; Evans, W. E. / Cisplatin-induced changes in bleomycin elimination. In: Cancer Treatment Reports. 1983 ; Vol. 67, No. 6. pp. 587-589.
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