Circulatory mechanisms underlying adaptive increases in thermogenic capacity in high-altitude deer mice

Kevin B. Tate, Catherine M. Ivy, Jonathan P. Velotta, Jay F. Storz, Grant B. McClelland, Zachary A. Cheviron, Graham R. Scott

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We examined the circulatory mechanisms underlying adaptive increases in thermogenic capacity in deer mice (Peromyscus maniculatus) native to the cold hypoxic environment at high altitudes. Deer mice from high- and low-altitude populations were born and raised in captivity to adulthood, and then acclimated to normoxia or hypobaric hypoxia (simulating hypoxia at ∼4300 m). Thermogenic capacity [maximal O2 consumption (V̇O2,max), during cold exposure] was measured in hypoxia, along with arterial O2 saturation (SaO2) and heart rate (fH). Hypoxia acclimation increased V̇O2,max by a greater magnitude in highlanders than in lowlanders. Highlanders also had higher SaO2 and extracted more O2 from the blood per heartbeat (O2 pulse=V̇O2,max/fH). Hypoxia acclimation increased fH, O2 pulse and capillary density in the left ventricle of the heart. Our results suggest that adaptive increases in thermogenic capacity involve integrated functional changes across the O2 cascade that augment O2 circulation and extraction from the blood.

Original languageEnglish (US)
Pages (from-to)3616-3620
Number of pages5
JournalJournal of Experimental Biology
Volume220
Issue number20
DOIs
StatePublished - Oct 15 2017

Fingerprint

Peromyscus
hypoxia
deer
Acclimatization
acclimation
Pulse
blood
heart ventricle
functional change
Peromyscus maniculatus
normoxia
Blood Circulation
captivity
adulthood
Heart Ventricles
heart rate
Heart Rate
Hypoxia
saturation
Population

Keywords

  • Aerobic performance
  • Evolutionary physiology
  • High-altitude adaptation
  • O transport pathway
  • Respiration

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Physiology
  • Aquatic Science
  • Animal Science and Zoology
  • Molecular Biology
  • Insect Science

Cite this

Tate, K. B., Ivy, C. M., Velotta, J. P., Storz, J. F., McClelland, G. B., Cheviron, Z. A., & Scott, G. R. (2017). Circulatory mechanisms underlying adaptive increases in thermogenic capacity in high-altitude deer mice. Journal of Experimental Biology, 220(20), 3616-3620. https://doi.org/10.1242/jeb.164491

Circulatory mechanisms underlying adaptive increases in thermogenic capacity in high-altitude deer mice. / Tate, Kevin B.; Ivy, Catherine M.; Velotta, Jonathan P.; Storz, Jay F.; McClelland, Grant B.; Cheviron, Zachary A.; Scott, Graham R.

In: Journal of Experimental Biology, Vol. 220, No. 20, 15.10.2017, p. 3616-3620.

Research output: Contribution to journalArticle

Tate, Kevin B. ; Ivy, Catherine M. ; Velotta, Jonathan P. ; Storz, Jay F. ; McClelland, Grant B. ; Cheviron, Zachary A. ; Scott, Graham R. / Circulatory mechanisms underlying adaptive increases in thermogenic capacity in high-altitude deer mice. In: Journal of Experimental Biology. 2017 ; Vol. 220, No. 20. pp. 3616-3620.
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