Circadian locomotor rhythms in the desert iguana - II. Effects of electrolytic lesions to the hypothalamus

Daniel S. Janik, Gary E. Pickard, Michael Menaker

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Desert iguanas, Dipsosaurus dorsalis, displaying freerunning circadian locomotor rhythms in conditions of constant darkness and temperature received electrolytic lesions to the hypothalamus. The locomotor activity of those lizards (N = 9) which sustained 80% or more damage to the suprachiasmatic nucleus (SCN) became arrhythmic whereas all animals that sustained less than 35% damage to the SCN remained rhythmic, even though they sustained significant damage to nearby regions of the hypothalamus and preoptic area. These results suggest strongly that the SCN plays a role in the regulation of circadian rhythms in the desert iguana. Taken together with other evidence, they support the view that this structure is homologous to the mammalian SCN, which acts as a pacemaker in the circadian system.

Original languageEnglish (US)
Pages (from-to)811-816
Number of pages6
JournalJournal of Comparative Physiology A
Volume166
Issue number6
DOIs
StatePublished - Apr 1 1990

Fingerprint

Iguanas
circadian rhythm
Suprachiasmatic Nucleus
hypothalamus
Circadian Rhythm
lesion
lesions (animal)
Hypothalamus
desert
damage
preoptic area
lizard
Preoptic Area
locomotion
Lizards
lizards
Darkness
Locomotion
animal
Temperature

Keywords

  • Circadian
  • Hypothalamus
  • Lesion
  • Lizard
  • Suprachiasmatic nucleus

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Physiology
  • Animal Science and Zoology
  • Behavioral Neuroscience

Cite this

Circadian locomotor rhythms in the desert iguana - II. Effects of electrolytic lesions to the hypothalamus. / Janik, Daniel S.; Pickard, Gary E.; Menaker, Michael.

In: Journal of Comparative Physiology A, Vol. 166, No. 6, 01.04.1990, p. 811-816.

Research output: Contribution to journalArticle

@article{aee492868ffb46c5babd30b59c12abe7,
title = "Circadian locomotor rhythms in the desert iguana - II. Effects of electrolytic lesions to the hypothalamus",
abstract = "Desert iguanas, Dipsosaurus dorsalis, displaying freerunning circadian locomotor rhythms in conditions of constant darkness and temperature received electrolytic lesions to the hypothalamus. The locomotor activity of those lizards (N = 9) which sustained 80{\%} or more damage to the suprachiasmatic nucleus (SCN) became arrhythmic whereas all animals that sustained less than 35{\%} damage to the SCN remained rhythmic, even though they sustained significant damage to nearby regions of the hypothalamus and preoptic area. These results suggest strongly that the SCN plays a role in the regulation of circadian rhythms in the desert iguana. Taken together with other evidence, they support the view that this structure is homologous to the mammalian SCN, which acts as a pacemaker in the circadian system.",
keywords = "Circadian, Hypothalamus, Lesion, Lizard, Suprachiasmatic nucleus",
author = "Janik, {Daniel S.} and Pickard, {Gary E.} and Michael Menaker",
year = "1990",
month = "4",
day = "1",
doi = "10.1007/BF00187327",
language = "English (US)",
volume = "166",
pages = "811--816",
journal = "Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology",
issn = "0340-7594",
publisher = "Springer Verlag",
number = "6",

}

TY - JOUR

T1 - Circadian locomotor rhythms in the desert iguana - II. Effects of electrolytic lesions to the hypothalamus

AU - Janik, Daniel S.

AU - Pickard, Gary E.

AU - Menaker, Michael

PY - 1990/4/1

Y1 - 1990/4/1

N2 - Desert iguanas, Dipsosaurus dorsalis, displaying freerunning circadian locomotor rhythms in conditions of constant darkness and temperature received electrolytic lesions to the hypothalamus. The locomotor activity of those lizards (N = 9) which sustained 80% or more damage to the suprachiasmatic nucleus (SCN) became arrhythmic whereas all animals that sustained less than 35% damage to the SCN remained rhythmic, even though they sustained significant damage to nearby regions of the hypothalamus and preoptic area. These results suggest strongly that the SCN plays a role in the regulation of circadian rhythms in the desert iguana. Taken together with other evidence, they support the view that this structure is homologous to the mammalian SCN, which acts as a pacemaker in the circadian system.

AB - Desert iguanas, Dipsosaurus dorsalis, displaying freerunning circadian locomotor rhythms in conditions of constant darkness and temperature received electrolytic lesions to the hypothalamus. The locomotor activity of those lizards (N = 9) which sustained 80% or more damage to the suprachiasmatic nucleus (SCN) became arrhythmic whereas all animals that sustained less than 35% damage to the SCN remained rhythmic, even though they sustained significant damage to nearby regions of the hypothalamus and preoptic area. These results suggest strongly that the SCN plays a role in the regulation of circadian rhythms in the desert iguana. Taken together with other evidence, they support the view that this structure is homologous to the mammalian SCN, which acts as a pacemaker in the circadian system.

KW - Circadian

KW - Hypothalamus

KW - Lesion

KW - Lizard

KW - Suprachiasmatic nucleus

UR - http://www.scopus.com/inward/record.url?scp=0024992202&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024992202&partnerID=8YFLogxK

U2 - 10.1007/BF00187327

DO - 10.1007/BF00187327

M3 - Article

C2 - 2359055

AN - SCOPUS:0024992202

VL - 166

SP - 811

EP - 816

JO - Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology

JF - Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology

SN - 0340-7594

IS - 6

ER -