Circadian disruption and surgical recovery

Lynne A. Farr, C. Campbell-Ghossman, J. M. Mack

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Circadian rhythms were investigated in rats following surgery, as measured by body temperature and locomotor activity, and postoperative recovery was measured by activity level. Eight randomly selected Sprague-Dawley rats were implanted with radio temperature-transmitters under general anesthesia. Timer-controlled cassette recorders recorded body temperature at predetermined intervals. To monitor activity, the rats were placed in individual metabolic cages equipped with infrared-sensitive locomotor activity monitors. Temperature was sampled hourly. Activity was measured continuously and summed every 15 minutes for sampling. Measurement was begun before surgery and continued from 12 to 20 days following surgery, depending on when the animals regained their typical rhythmic patterns. Temperature and activity rhythms were altered and uncoupled from external cues in a manner similar to that previously found in humans. The animals demonstrated individual variation in their return to presurgical activity levels. Six days after surgery, the rats experienced a second period of disrhythmic and decreased activity. Rats with the greatest activity phase-shifts took longest to return to presurgical activity levels. This suggests that the degree of circadian alteration following surgery is positively related to the time required for recovery and reentrainment of rhythmicity.

Original languageEnglish (US)
Pages (from-to)170-175
Number of pages6
JournalNursing research
Volume37
Issue number3
StatePublished - Jan 1 1988

Fingerprint

Locomotion
Body Temperature
Ambulatory Surgical Procedures
Temperature
Periodicity
Circadian Rhythm
Radio
General Anesthesia
Cues
Sprague Dawley Rats

ASJC Scopus subject areas

  • Nursing(all)

Cite this

Farr, L. A., Campbell-Ghossman, C., & Mack, J. M. (1988). Circadian disruption and surgical recovery. Nursing research, 37(3), 170-175.

Circadian disruption and surgical recovery. / Farr, Lynne A.; Campbell-Ghossman, C.; Mack, J. M.

In: Nursing research, Vol. 37, No. 3, 01.01.1988, p. 170-175.

Research output: Contribution to journalArticle

Farr, LA, Campbell-Ghossman, C & Mack, JM 1988, 'Circadian disruption and surgical recovery', Nursing research, vol. 37, no. 3, pp. 170-175.
Farr, Lynne A. ; Campbell-Ghossman, C. ; Mack, J. M. / Circadian disruption and surgical recovery. In: Nursing research. 1988 ; Vol. 37, No. 3. pp. 170-175.
@article{8951edc80f8a4840a2f3b7372f581542,
title = "Circadian disruption and surgical recovery",
abstract = "Circadian rhythms were investigated in rats following surgery, as measured by body temperature and locomotor activity, and postoperative recovery was measured by activity level. Eight randomly selected Sprague-Dawley rats were implanted with radio temperature-transmitters under general anesthesia. Timer-controlled cassette recorders recorded body temperature at predetermined intervals. To monitor activity, the rats were placed in individual metabolic cages equipped with infrared-sensitive locomotor activity monitors. Temperature was sampled hourly. Activity was measured continuously and summed every 15 minutes for sampling. Measurement was begun before surgery and continued from 12 to 20 days following surgery, depending on when the animals regained their typical rhythmic patterns. Temperature and activity rhythms were altered and uncoupled from external cues in a manner similar to that previously found in humans. The animals demonstrated individual variation in their return to presurgical activity levels. Six days after surgery, the rats experienced a second period of disrhythmic and decreased activity. Rats with the greatest activity phase-shifts took longest to return to presurgical activity levels. This suggests that the degree of circadian alteration following surgery is positively related to the time required for recovery and reentrainment of rhythmicity.",
author = "Farr, {Lynne A.} and C. Campbell-Ghossman and Mack, {J. M.}",
year = "1988",
month = "1",
day = "1",
language = "English (US)",
volume = "37",
pages = "170--175",
journal = "Nursing Research",
issn = "0029-6562",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Circadian disruption and surgical recovery

AU - Farr, Lynne A.

AU - Campbell-Ghossman, C.

AU - Mack, J. M.

PY - 1988/1/1

Y1 - 1988/1/1

N2 - Circadian rhythms were investigated in rats following surgery, as measured by body temperature and locomotor activity, and postoperative recovery was measured by activity level. Eight randomly selected Sprague-Dawley rats were implanted with radio temperature-transmitters under general anesthesia. Timer-controlled cassette recorders recorded body temperature at predetermined intervals. To monitor activity, the rats were placed in individual metabolic cages equipped with infrared-sensitive locomotor activity monitors. Temperature was sampled hourly. Activity was measured continuously and summed every 15 minutes for sampling. Measurement was begun before surgery and continued from 12 to 20 days following surgery, depending on when the animals regained their typical rhythmic patterns. Temperature and activity rhythms were altered and uncoupled from external cues in a manner similar to that previously found in humans. The animals demonstrated individual variation in their return to presurgical activity levels. Six days after surgery, the rats experienced a second period of disrhythmic and decreased activity. Rats with the greatest activity phase-shifts took longest to return to presurgical activity levels. This suggests that the degree of circadian alteration following surgery is positively related to the time required for recovery and reentrainment of rhythmicity.

AB - Circadian rhythms were investigated in rats following surgery, as measured by body temperature and locomotor activity, and postoperative recovery was measured by activity level. Eight randomly selected Sprague-Dawley rats were implanted with radio temperature-transmitters under general anesthesia. Timer-controlled cassette recorders recorded body temperature at predetermined intervals. To monitor activity, the rats were placed in individual metabolic cages equipped with infrared-sensitive locomotor activity monitors. Temperature was sampled hourly. Activity was measured continuously and summed every 15 minutes for sampling. Measurement was begun before surgery and continued from 12 to 20 days following surgery, depending on when the animals regained their typical rhythmic patterns. Temperature and activity rhythms were altered and uncoupled from external cues in a manner similar to that previously found in humans. The animals demonstrated individual variation in their return to presurgical activity levels. Six days after surgery, the rats experienced a second period of disrhythmic and decreased activity. Rats with the greatest activity phase-shifts took longest to return to presurgical activity levels. This suggests that the degree of circadian alteration following surgery is positively related to the time required for recovery and reentrainment of rhythmicity.

UR - http://www.scopus.com/inward/record.url?scp=0023945993&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023945993&partnerID=8YFLogxK

M3 - Article

C2 - 3368358

AN - SCOPUS:0023945993

VL - 37

SP - 170

EP - 175

JO - Nursing Research

JF - Nursing Research

SN - 0029-6562

IS - 3

ER -