Abstract
While many genetic defects have been determined to compromise ciliary function, the detrimental effects of alcohol and other environmental factors can also cause ciliary dysfunction-a condition we call an ". acquired ciliopathy." In this chapter, we focus on the impact of alcohol exposure on ciliary function. Alcohol-induced ciliary dysfunction (AICD) occurs with prolonged alcohol consumption and results in compromised lung function, in part, due to loss of airway cilia responsiveness resulting in impaired mucociliary clearance. In particular, we detail the impact of alcohol (ethanol) on the mammalian lung and airway cilia, discussing the effects of both brief and prolonged alcohol exposure. We summarize recent work demonstrating AICD in the model protist, Chlamydomonas reinhardtii, and the discovery of specific ciliary targets of alcohol. This chapter concludes with a section discussing new questions, future directions, and potential treatments for AICD.
| Original language | English (US) |
|---|---|
| Title of host publication | Dyneins |
| Subtitle of host publication | Dynein Mechanics, Dysfunction, and Disease: Second Edition |
| Publisher | Elsevier |
| Pages | 402-417 |
| Number of pages | 16 |
| Volume | 2 |
| ISBN (Electronic) | 9780128097014 |
| ISBN (Print) | 9780128094709 |
| DOIs | |
| State | Published - Jan 1 2018 |
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Keywords
- Acquired ciliopathy
- Alcohol
- Axoneme
- Cilia
- Dynein motors
- Ethanol
- Flagella
- Lung
- Mucociliary clearance
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Ciliary dynein dysfunction caused by chronic alcohol exposure. / Price, Michael; Yang, Fan; Sisson, Joseph Harold; Wirschell, Maureen.
Dyneins: Dynein Mechanics, Dysfunction, and Disease: Second Edition. Vol. 2 Elsevier, 2018. p. 402-417.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Ciliary dynein dysfunction caused by chronic alcohol exposure
AU - Price, Michael
AU - Yang, Fan
AU - Sisson, Joseph Harold
AU - Wirschell, Maureen
PY - 2018/1/1
Y1 - 2018/1/1
N2 - While many genetic defects have been determined to compromise ciliary function, the detrimental effects of alcohol and other environmental factors can also cause ciliary dysfunction-a condition we call an ". acquired ciliopathy." In this chapter, we focus on the impact of alcohol exposure on ciliary function. Alcohol-induced ciliary dysfunction (AICD) occurs with prolonged alcohol consumption and results in compromised lung function, in part, due to loss of airway cilia responsiveness resulting in impaired mucociliary clearance. In particular, we detail the impact of alcohol (ethanol) on the mammalian lung and airway cilia, discussing the effects of both brief and prolonged alcohol exposure. We summarize recent work demonstrating AICD in the model protist, Chlamydomonas reinhardtii, and the discovery of specific ciliary targets of alcohol. This chapter concludes with a section discussing new questions, future directions, and potential treatments for AICD.
AB - While many genetic defects have been determined to compromise ciliary function, the detrimental effects of alcohol and other environmental factors can also cause ciliary dysfunction-a condition we call an ". acquired ciliopathy." In this chapter, we focus on the impact of alcohol exposure on ciliary function. Alcohol-induced ciliary dysfunction (AICD) occurs with prolonged alcohol consumption and results in compromised lung function, in part, due to loss of airway cilia responsiveness resulting in impaired mucociliary clearance. In particular, we detail the impact of alcohol (ethanol) on the mammalian lung and airway cilia, discussing the effects of both brief and prolonged alcohol exposure. We summarize recent work demonstrating AICD in the model protist, Chlamydomonas reinhardtii, and the discovery of specific ciliary targets of alcohol. This chapter concludes with a section discussing new questions, future directions, and potential treatments for AICD.
KW - Acquired ciliopathy
KW - Alcohol
KW - Axoneme
KW - Cilia
KW - Dynein motors
KW - Ethanol
KW - Flagella
KW - Lung
KW - Mucociliary clearance
UR - http://www.scopus.com/inward/record.url?scp=85042281121&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85042281121&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-809470-9.00016-3
DO - 10.1016/B978-0-12-809470-9.00016-3
M3 - Chapter
SN - 9780128094709
VL - 2
SP - 402
EP - 417
BT - Dyneins
PB - Elsevier
ER -